抗ccp抗体:类风湿关节炎早期诊断的新兴标志物

IF 0.3 Q3 MEDICINE, GENERAL & INTERNAL

International Medical Journal Malaysia Pub Date : 2020-11-17 DOI:10.31436/IMJM.V9I1.745

K. Sarah, A. Nadeem

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引用次数: 1

摘要

摘要类风湿性关节炎（RA）是一种主要影响关节的系统性疾病。由于类风湿性关节炎是一个常见的全球性问题，因此准确诊断这种疾病至关重要。在过去，类风湿因子被认为是诊断这种疾病的唯一标志物；然而，类风湿因子存在于许多其他疾病中，甚至高达15%的健康人群中。对于类风湿性关节炎的检测，多年来已经报道了许多自身抗体，如抗核周因子（APF）和抗角蛋白抗体（AKA），但它们不是特异性的，并且由于用于实验室诊断的繁琐程序，它们不能在该疾病的诊断中流行起来。最近已经报道了抗CCP抗体，并且由于其高灵敏度和特异性而变得流行起来。人们希望在几年后，抗CCP抗体可以被纳入诊断RA的ACR标准。关键词：类风湿因子、抗核周因子、抗角蛋白抗体、抗环瓜氨酸肽抗体

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Anti-CCP Antibodies: an Emerging Marker for the Early Diagnosis of Rheumatoid Arthritis

ABSTRACT Rheumatoid arthritis (RA) is a systemic disease affecting mainly joints. Since rheumatoid arthritis is a common and a world wide problem therefore accurate diagnosis of this disease is essential. In the past rheumatoid factor was considered as the only marker for diagnosing this disease; however rheumatoid factor is present in many other disorders and even in up to 15% of healthy population. For the detection of rheumatoid arthritis, over the years many auto antibodies have been reported such as anti perinuclear factor (APF) and anti keratin antibodies (AKA) but they were not specifi c and due to the tedious procedure used for their laboratory diagnosis, they could not become popular for the diagnosis of this disease. Recently anti-CCP antibodies have been reported and they are becoming popular due to their high sensitivity and specifi city. It is hoped that in a couple of years time anti-CCP antibodies could be included in the ACR criteria for diagnosing RA. KEYWORDS: Rheumatoid factor, anti perinuclear factor, anti keratin antibodies, anti-cyclic citrullinated peptide antibodies

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来源期刊

International Medical Journal Malaysia Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： International Medical Journal Malaysia (IMJM) is the official journal of the Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. It serves primarily as a forum for education and intellectual discourse for health professionals namely in clinical medicine but covers diverse issues relating to medical ethics, professionalism as well as medical developments and research in basic medical sciences. It also serves the unique purpose of highlighting issues and research pertaining to the Muslim world. Contributions to the IMJM reflect its international and multidisciplinary readership and include current thinking across a range of specialties, ethnicities and societies.