基于萘衍生物的荧光探针精氨酸检测及细胞毒性研究

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Heteroatom Chemistry Pub Date : 2018-11-12 DOI:10.1002/hc.21449

Xuefang Shang, Congshu Li, Jie Li, Yanmei Chen, Hongli Chen, Tianyun Wang

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引用次数: 2

摘要

从生物学的角度来看，含有荧光基团的希夫碱探针进行了化学修饰，为氨基酸的检测提供了一种有效的方法。根据这种方法，设计并合成了三种含席夫碱和羟基的分子探针。紫外-可见和荧光数据表明，化合物2在正常的20种氨基酸中对精氨酸(Arg)具有较强的敏感性和较高的选择性。化合物2在0 ~ 150 μg/mL的MCF-7细胞中具有较强的Arg结合能力和较低的细胞毒性。上述结果表明，所合成的探针也可以作为生物传感器用于体内精氨酸的检测。

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The arginine detection and cytotoxicity of fluorescent probes based on naphthalene derivatives

From a biological point of view, Schiff base probes containing fluorescent groups are chemically modified to provide an effective method for the detection of amino acids. According to this method, three molecular probes containing Schiff base and hydroxyl group have been designed and synthesized. UV-Vis and fluorescent data indicated that compound 2 showed strong sensitivity and high selectivity for arginine (Arg) among normal twenty kinds of amino acids. In addition, compound 2 displayed high combining ability with Arg and low cytotoxicity in MCF-7 cell from 0 to 150 μg/mL. The above results showed the synthesized probes also can be used a biosensor for the Arg detection in vivo.

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来源期刊

Heteroatom Chemistry 化学-化学综合

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Heteroatom Chemistry brings together a broad, interdisciplinary group of chemists who work with compounds containing main-group elements of groups 13 through 17 of the Periodic Table, and certain other related elements. The fundamental reactivity under investigation should, in all cases, be concentrated about the heteroatoms. It does not matter whether the compounds being studied are acyclic or cyclic; saturated or unsaturated; monomeric, polymeric or solid state in nature; inorganic, organic, or naturally occurring, so long as the heteroatom is playing an essential role. Computational, experimental, and combined studies are equally welcome. Subject areas include (but are by no means limited to): -Reactivity about heteroatoms for accessing new products or synthetic pathways -Unusual valency main-group element compounds and their properties -Highly strained (e.g. bridged) main-group element compounds and their properties -Photochemical or thermal cleavage of heteroatom bonds and the resulting reactivity -Uncommon and structurally interesting heteroatom-containing species (including those containing multiple bonds and catenation) -Stereochemistry of compounds due to the presence of heteroatoms -Neighboring group effects of heteroatoms on the properties of compounds -Main-group element compounds as analogues of transition metal compounds -Variations and new results from established and named reactions (including Wittig, Kabachnik–Fields, Pudovik, Arbuzov, Hirao, and Mitsunobu) -Catalysis and green syntheses enabled by heteroatoms and their chemistry -Applications of compounds where the heteroatom plays a critical role. In addition to original research articles on heteroatom chemistry, the journal welcomes focused review articles that examine the state of the art, identify emerging trends, and suggest future directions for developing fields.