COVID-19患者急性肾损伤及相关危险因素调查

IF 0.2 Q4 UROLOGY & NEPHROLOGY

Journal of Renal Injury Prevention Pub Date : 2021-07-13 DOI:10.34172/jrip.2022.27829

B. Hadian, Azita Zafarmohtashami, Mahdi Razani

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引用次数: 0

摘要

2019新型冠状病毒病(COVID- 19)是一种新型的世界性大流行疾病。这种病毒性败血症的主要器官是呼吸系统。目的:考虑到血管紧张素转换酶受体的表达是病毒颗粒进入细胞的途径，肾脏器官是这种灾难性败血症的另一个重要靶点。关于受害者肾脏并发症和相关危险因素的数据很少。患者和方法:所有转诊和三级中心(伊朗霍拉马巴德Shohada医院)的COVID-19患者均纳入研究。该研究于2020年2月20日至4月19日进行。采用实时聚合酶链反应(real-time PCR)采集COVID-19上呼吸道样本，确认患者诊断。根据考虑的因素，将患者的人口学数据、临床和实验室变量纳入预先设计的问卷;将收集到的数据输入SPSS-26软件进行统计分析。结果:纳入研究的COVID-19患者共232例。其中女性99例(42.7%)，男性133例(57.3%)。患者中有AKI(急性肾损伤)19例;在这些案例中。在AKI患者中，12例(63.2%)入住ICU，而AKI患者的死亡率为63.2%。AKI与老年、ICU住院和低淋巴细胞计数显著相关。AKI的发生与高血压病史或潜在肾脏疾病相关，但与糖尿病无显著关系。结论:根据本研究，年龄是COVID-19患者肾脏疾病和预后不良的重要危险因素。因此，老年患者应该给予更多的关注。对于更普遍的钾障碍，建议进一步监测低钾血症或高钾血症。考虑到COVID-19和AKI患者预后不良，肾病专家咨询是必要的。

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Investigation of acute kidney injury and related risk factors in patients with COVID-19

Introduction: The 2019 recent coronavirus disease (COVID- 19) is a novel pandemic disease in the world. The main organ involved in this viral sepsis is the respiratory system. Objectives: Regarding the expression of angiotensin-converting enzyme (ACE) receptors as entering route for virus’ particles into cells, the kidney organ is another important target in this catastrophic sepsis. There is little data about renal complications and related risk factors in victims. Patients and Methods: All patients with COVID-19 admitted to a referral and tertiary center (Shohada hospital, Khorramabad, Iran) were included in the study. The research was performed from February 20 to April 19, 2020. Diagnosis of patients was confirmed by COVID-19 upper respiratory sampling using real-time PCR. Patients’ demographic data, clinical and laboratory variables were included in pre-designed questionnaires according to the considered factors; then all collected data was entered into SPSS-26 software and statistical analysis was performed. Results: All COVID-19 patients included in the study were 232 cases. Out of them, 99 cases were female (42.7%) and 133 males (57.3%). Among patients, 19 cases had AKI (acute kidney injury); of these cases. Out of AKI patients, 12 (63.2%) were admitted to the ICU, whereas the mortality rate in patients with AKI was 63.2%. AKI was significantly associated with older age, ICU admission, and lower lymphocyte count. AKI occurrence was associated with the history of hypertension, or underlying kidney disease but hadn’t a significant relationship with diabetes. Conclusion: According to this study, age is an important risk factor for renal disease and poor outcomes in COVID-19 patients. Hence, old age patients should be given more attention. Concerning more prevalence of potassium disorders, further monitoring of hypokalemia or hyperkalemia is recommended. Considering, poor outcomes in patients with COVID-19 and AKI, nephrologist’s consultation is necessary.

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.