代谢综合征和2型糖尿病中有机因子的炎性暗示

IF 1.8 4区 综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES
Suktara Guria, Soumyadeep Basu, Anupama Hoory, Sutapa Mukherjee, Satinath Mukhopadhyay
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引用次数: 0

摘要

肥胖及其相关的代谢紊乱已成为一项重大的全球健康挑战。异位脂肪积累破坏代谢稳态,导致代谢综合征(MetS)、2型糖尿病(T2D)和心血管疾病。T2D与脂肪组织、肝脏和骨骼肌的慢性低度炎症密切相关。由这些器官合成的分泌蛋白,即脂肪因子、肝因子和肌因子,统称为有机因子,它们通过内分泌、自分泌和旁分泌途径相互作用,在胰岛素靶组织中产生复杂的作用。由于有机因子具有促炎和抗炎作用,因此它们之间的最佳平衡对代谢稳态至关重要。这篇综述的目的是关注在当代研究中被确定为炎症的主要调节因子的一些有机因子的功能,导致代谢性疾病的发生和进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Inflammatory Overtones of Organokines in Metabolic Syndrome and Type 2 Diabetes

Inflammatory Overtones of Organokines in Metabolic Syndrome and Type 2 Diabetes

Obesity and its associated metabolic derangements have become a major global health challenge. Ectopic fat accumulation disrupts metabolic homeostasis leading to metabolic syndrome (MetS), type 2 diabetes (T2D), and cardiovascular diseases. T2D is strongly associated with chronic low-grade inflammation in the adipose tissue, liver, and arguably in the skeletal muscle. Secretory proteins elaborated by these organs, i.e., adipokines, hepatokines, and myokines, are collectively grouped as organokines, which interact with each other to produce complex effects in insulin target tissues through endocrine, autocrine, and paracrine pathways. Since organokines have both proinflammatory and anti-inflammatory effects, the optimum balance between them is critical for metabolic homeostasis. The goal of this review is to focus on the functions of some of these organokines that have been identified in contemporary research as major regulators of inflammation, leading to the onset and progression of metabolic diseases.

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来源期刊
Journal of the Indian Institute of Science
Journal of the Indian Institute of Science MULTIDISCIPLINARY SCIENCES-
CiteScore
4.30
自引率
0.00%
发文量
75
期刊介绍: Started in 1914 as the second scientific journal to be published from India, the Journal of the Indian Institute of Science became a multidisciplinary reviews journal covering all disciplines of science, engineering and technology in 2007. Since then each issue is devoted to a specific topic of contemporary research interest and guest-edited by eminent researchers. Authors selected by the Guest Editor(s) and/or the Editorial Board are invited to submit their review articles; each issue is expected to serve as a state-of-the-art review of a topic from multiple viewpoints.
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