{"title":"代谢综合征和2型糖尿病中有机因子的炎性暗示","authors":"Suktara Guria, Soumyadeep Basu, Anupama Hoory, Sutapa Mukherjee, Satinath Mukhopadhyay","doi":"10.1007/s41745-023-00391-8","DOIUrl":null,"url":null,"abstract":"<div><p>Obesity and its associated metabolic derangements have become a major global health challenge. Ectopic fat accumulation disrupts metabolic homeostasis leading to metabolic syndrome (MetS), type 2 diabetes (T2D), and cardiovascular diseases. T2D is strongly associated with chronic low-grade inflammation in the adipose tissue, liver, and arguably in the skeletal muscle. Secretory proteins elaborated by these organs, i.e., adipokines, hepatokines, and myokines, are collectively grouped as <i>organokines</i>, which interact with each other to produce complex effects in insulin target tissues through endocrine, autocrine, and paracrine pathways. Since organokines have both proinflammatory and anti-inflammatory effects, the optimum balance between them is critical for metabolic homeostasis. The goal of this review is to focus on the functions of some of these organokines that have been identified in contemporary research as major regulators of inflammation, leading to the onset and progression of metabolic diseases.\n</p></div>","PeriodicalId":675,"journal":{"name":"Journal of the Indian Institute of Science","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inflammatory Overtones of Organokines in Metabolic Syndrome and Type 2 Diabetes\",\"authors\":\"Suktara Guria, Soumyadeep Basu, Anupama Hoory, Sutapa Mukherjee, Satinath Mukhopadhyay\",\"doi\":\"10.1007/s41745-023-00391-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Obesity and its associated metabolic derangements have become a major global health challenge. Ectopic fat accumulation disrupts metabolic homeostasis leading to metabolic syndrome (MetS), type 2 diabetes (T2D), and cardiovascular diseases. T2D is strongly associated with chronic low-grade inflammation in the adipose tissue, liver, and arguably in the skeletal muscle. Secretory proteins elaborated by these organs, i.e., adipokines, hepatokines, and myokines, are collectively grouped as <i>organokines</i>, which interact with each other to produce complex effects in insulin target tissues through endocrine, autocrine, and paracrine pathways. Since organokines have both proinflammatory and anti-inflammatory effects, the optimum balance between them is critical for metabolic homeostasis. The goal of this review is to focus on the functions of some of these organokines that have been identified in contemporary research as major regulators of inflammation, leading to the onset and progression of metabolic diseases.\\n</p></div>\",\"PeriodicalId\":675,\"journal\":{\"name\":\"Journal of the Indian Institute of Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2023-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Indian Institute of Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s41745-023-00391-8\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Indian Institute of Science","FirstCategoryId":"103","ListUrlMain":"https://link.springer.com/article/10.1007/s41745-023-00391-8","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Inflammatory Overtones of Organokines in Metabolic Syndrome and Type 2 Diabetes
Obesity and its associated metabolic derangements have become a major global health challenge. Ectopic fat accumulation disrupts metabolic homeostasis leading to metabolic syndrome (MetS), type 2 diabetes (T2D), and cardiovascular diseases. T2D is strongly associated with chronic low-grade inflammation in the adipose tissue, liver, and arguably in the skeletal muscle. Secretory proteins elaborated by these organs, i.e., adipokines, hepatokines, and myokines, are collectively grouped as organokines, which interact with each other to produce complex effects in insulin target tissues through endocrine, autocrine, and paracrine pathways. Since organokines have both proinflammatory and anti-inflammatory effects, the optimum balance between them is critical for metabolic homeostasis. The goal of this review is to focus on the functions of some of these organokines that have been identified in contemporary research as major regulators of inflammation, leading to the onset and progression of metabolic diseases.
期刊介绍:
Started in 1914 as the second scientific journal to be published from India, the Journal of the Indian Institute of Science became a multidisciplinary reviews journal covering all disciplines of science, engineering and technology in 2007. Since then each issue is devoted to a specific topic of contemporary research interest and guest-edited by eminent researchers. Authors selected by the Guest Editor(s) and/or the Editorial Board are invited to submit their review articles; each issue is expected to serve as a state-of-the-art review of a topic from multiple viewpoints.