新s-取代蝶呤的毒性和保肝性能评价

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL
N. Groma, G. Berest, O. Antypenko, O. Voskoboinik, V. Kopiika, S. Kovalenko, V. Shvets
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引用次数: 0

摘要

摘要肝损伤是世界各地常见的问题,通过服用各种药物来纠正这种疾病。天然和合成的含硫化合物在这方面是重要的。然而,其中大多数都有副作用,并不总是符合循证医学的标准。因此,寻找高效低毒、具有保肝作用的新药是当前药理学和生物化学亟待解决的问题。本研究的目的是评估新的具有潜在生物活性的S-取代蝶呤的急性毒性,选择毒性最小的物质,改善药物技术特性,并在大鼠四氯化碳肝炎实验模型中研究其肝保护特性。在此,化合物4.1和参考药物“Thiotriazoline”的肝保护特性的比较基于生化研究。研究结果表明,子条款4.1通过增加抗氧化系统的补偿机制,同时减少肝脏中的浸润、破坏和炎症过程,引起细胞溶解过程的减少,恢复肝细胞膜成分的结构,对生化过程产生积极影响,稳定和增强肝脏的功能活性,恢复肝脏的蛋白质合成功能,提高恢复肝脏代谢紊乱的能力。作为对化合物4.1的肝保护作用的生物化学研究的结果,发现所研究的物质是一种具有抗氧化特性的无毒化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the toxicity and hepatoprotective properties of new s-substituted pteridins
Abstract Liver damage is a common problem around the world, and pharmacocorrection of such disease is carried out by administration of various drugs. Natural and synthetic thio-containing compounds are important in this respect. Most of these, however, have side effects and do not always meet the criteria of evidence-based medicine. Therefore, the search for new drugs with hepatoprotective properties, characterized by high efficiency and low toxicity, is an urgent problem of current pharmacology and biochemistry. The purpose of this study was to assess the acute toxicity of new potentially bioactive S-substituted pteridinones, to select the least toxic substance, to improve the pharmaco-technological characteristics, and to study the hepatoprotective properties in an experimental model of tetrachloromethane hepatitis in rats. Herein, comparison of the hepatoprotective properties of compound 4.1 and the reference drug "Thiotriazoline" is based on biochemical studies. The research results showed that sub-stance 4.1 had a positive effect on biochemical processes by increasing the compensatory mechanisms of antioxidant systems, while reducing the infiltrative, destructive and inflamma-tory process in the liver, evoking decreases in the cytolytic process, restoring the structure of the components of the membrane of hepatocytes, stabilizing and enhancing the functional activity of the liver, restoring the liver’s protein-synthesizing function and increasing the abil-ity to restore metabolic disorders in the liver. As a result of the biochemical study of the hepa-toprotective effect of compound 4.1, it was found that the studied substance is a non-toxic compound with antioxidant properties.
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来源期刊
Current Issues in Pharmacy and Medical Sciences
Current Issues in Pharmacy and Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
0.80
自引率
0.00%
发文量
28
审稿时长
16 weeks
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