热塑性造粒颗粒压片的处方与评价

European Pharmaceutical Journal Pub Date : 2021-01-01 DOI:10.2478/afpuc-2021-0003

D. Kloc, T. Wolaschka, F. Ruttkay

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引用次数: 1

摘要

摘要:本配方研究的目的是考察热塑性造粒制备颗粒剂中粘结剂对心得安释放度的影响。另一个目的是选择合适的辅料及其在颗粒中的比例，以确保片剂的无故障配方。本研究证明，结合剂影响颗粒的流动特性，影响片剂的崩解，进而影响药物的释放方式，可用于制备改性或缓释片剂。

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Formulation and Evaluation of Tablets Compressed from Granules Prepared by Thermoplastic Granulation

Abstract The aim of this formulation study was to determine the effect of the binder used in the preparation of granules by thermoplastic granulation on the release of propranolol from experimental tablets. Another aim was to select suitable excipients and their ratio in the granules to ensure a trouble-free formulation of the tablets. This study proved that the binder affects the flow properties of the granules, disintegration of the tablets and, subsequently, also the method of drug release, which can be used for the preparation of tablets with modified or prolonged drug release.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.