扩散张量成像:一种有前途的准确识别延髓和Habenula的新技术

Q4 Medicine
O. Kheiralla, Aymen Abdalkariem, A. AlGhamdi, A. Tajaldeen, Naif Hamid
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引用次数: 0

摘要

髓纹(SM)是一种白质束,包含连接前脑认知-情绪区域和缰状核(Hb)的传入纤维。Hb通过对神经调节系统的作用,在对奖励、压力、焦虑、疼痛和睡眠的行为反应中起重要作用。后屈束(FR)形成Hb向中脑的主要输出。SM, Hb和FR是前脑和中脑之间的特殊通路的一部分,称为间脑背传导系统(DDC)。Hb功能障碍伴随着不同类型的神经精神疾病,如精神分裂症、抑郁症和难治性抑郁症(TRD)。由于SM和HB在体内的成像评估困难,它们一直没有成为临床研究的重点,直到弥散张量成像(DTI)的发明,它彻底改变了SM和HB的成像和研究。DTI促进了SM和Hb的成像,并通过对其单胺失调的研究提供了对其特性的见解。DTI是一种成熟的脑结构和白质束测绘技术;它基于水在细胞内和细胞外空间的扩散特性,如轴向扩散率(AD)、径向扩散率(RD)、平均扩散率和分数各向异性(FA),提供了体内白质微观结构和完整性的间接信息。神经外科医生已经认识到DTI在深部脑刺激(DBS)手术治疗某些神经精神疾病(如TRD)之前直接解剖靶向SM和Hb的潜在价值。DTI是唯一的非侵入性的方法,提供了可视化的可能性,白质束和核在人的大脑。本综述总结了DTI作为一种有前景的准确识别SM和Hb的新成像方法的使用,特别强调了在DBS手术前对SM和Hb的直接解剖靶向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diffusion Tensor Imaging: A Promising New Technique for Accurate Identification of the Stria Medullaris and Habenula
The Stria Medullaris (SM) is a white-matter tract that contains afferent fibres that connect the cognitive-emotional areas in the forebrain to the Habenula (Hb). The Hb plays an important role in behavioral responses to reward, stress, anxiety, pain, and sleep through its action on neuromodulator systems. The Fasciculus Retroflexus (FR) forms the primary output of the Hb to the midbrain. The SM, Hb, and FR are part of a special pathway between the forebrain and the midbrain known as the Dorsal Diencephalic Conduction system (DDC). Hb dysfunction is accompanied by different types of neuropsychiatric disorders, such as schizophrenia, depression, and Treatment-Resistant Depression (TRD). Due to difficulties in the imaging assessment of the SM and HB in vivo, they had not been a focus of clinical studies until the invention of Diffusion Tensor Imaging (DTI), which has revolutionized the imaging and investigation of the SM and Hb. DTI has facilitated the imaging of the SM and Hb and has provided insights into their properties through the investigation of their monoamine dysregulation. DTI is a well-established technique for mapping brain microstructure and white matter tracts; it provides indirect information about the microstructural architecture and integrity of white matter in vivo, based on water diffusion properties in the intraand extracellular space, such as Axial Diffusivity (AD), Radial Diffusivity (RD), mean diffusivity, and Fractional Anisotropy (FA). Neurosurgeons have recognized the potential value of DTI in the direct anatomical targeting of the SM and Hb prior to Deep Brain Stimulation (DBS) surgery for the treatment of certain neuropsychiatric conditions, such as TRD. DTI is the only non-invasive method that offers the possibility of visualization in vivo of the white-matter tracts and nuclei in the human brain. This review study summarizes the use of DTI as a promising new imaging method for accurate identification of the SM and Hb, with special emphasis on direct anatomical targeting of the SM and Hb prior to DBS surgery.
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来源期刊
Open Neuroimaging Journal
Open Neuroimaging Journal Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.70
自引率
0.00%
发文量
3
期刊介绍: The Open Neuroimaging Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, and letters in all important areas of brain function, structure and organization including neuroimaging, neuroradiology, analysis methods, functional MRI acquisition and physics, brain mapping, macroscopic level of brain organization, computational modeling and analysis, structure-function and brain-behavior relationships, anatomy and physiology, psychiatric diseases and disorders of the nervous system, use of imaging to the understanding of brain pathology and brain abnormalities, cognition and aging, social neuroscience, sensorimotor processing, communication and learning.
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