在比利苹果®的生命中，肠道微生物群的长期稳定性超过46 年

Q1 Medicine

Human Microbiome Journal Pub Date : 2017-12-01 DOI:10.1016/j.humic.2017.09.001

Thilini N. Jayasinghe , Craig Hilton , Peter Tsai , Billy Apple , Peter Shepherd , Wayne S. Cutfield , Justin M. O'Sullivan

{"title":"在比利苹果®的生命中，肠道微生物群的长期稳定性超过46 年","authors":"Thilini N. Jayasinghe , Craig Hilton , Peter Tsai , Billy Apple , Peter Shepherd , Wayne S. Cutfield , Justin M. O'Sullivan","doi":"10.1016/j.humic.2017.09.001","DOIUrl":null,"url":null,"abstract":"<div><p>There is currently a lack of long-term longitudinal studies investigating the stability of the microbiome. In this n-of-one study, we characterised the gut microbial composition of artist Billy Apple® from stool samples collected 45 years apart in 1970 and 2016. We observed that 45% of the microbial species were retained over the 45 year interval. Moreover, components of Apple’s microbiome associated with the allele frequency at seven SNPs in his genome. Collectively, our results are consistent with a genetic component contributing to the selection and maintenance of core members within the artist’s microbiome over his life-time.</p></div>","PeriodicalId":37790,"journal":{"name":"Human Microbiome Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.humic.2017.09.001","citationCount":"8","resultStr":"{\"title\":\"Long-term stability in the gut microbiome over 46 years in the life of Billy Apple®\",\"authors\":\"Thilini N. Jayasinghe , Craig Hilton , Peter Tsai , Billy Apple , Peter Shepherd , Wayne S. Cutfield , Justin M. O'Sullivan\",\"doi\":\"10.1016/j.humic.2017.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>There is currently a lack of long-term longitudinal studies investigating the stability of the microbiome. In this n-of-one study, we characterised the gut microbial composition of artist Billy Apple® from stool samples collected 45 years apart in 1970 and 2016. We observed that 45% of the microbial species were retained over the 45 year interval. Moreover, components of Apple’s microbiome associated with the allele frequency at seven SNPs in his genome. Collectively, our results are consistent with a genetic component contributing to the selection and maintenance of core members within the artist’s microbiome over his life-time.</p></div>\",\"PeriodicalId\":37790,\"journal\":{\"name\":\"Human Microbiome Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.humic.2017.09.001\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human Microbiome Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S245223171730009X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Microbiome Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S245223171730009X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 8

摘要

目前缺乏对微生物组稳定性的长期纵向研究。在这项n-of- 1研究中，我们从1970年和2016年相隔45 年收集的粪便样本中描述了艺术家Billy Apple®的肠道微生物组成。我们观察到45%的微生物物种在45 年的间隔中被保留。此外，苹果的微生物组成分与他基因组中七个snp的等位基因频率相关。总的来说，我们的结果与遗传成分一致，这些遗传成分有助于艺术家一生中微生物群中的核心成员的选择和维持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Long-term stability in the gut microbiome over 46 years in the life of Billy Apple®

There is currently a lack of long-term longitudinal studies investigating the stability of the microbiome. In this n-of-one study, we characterised the gut microbial composition of artist Billy Apple® from stool samples collected 45 years apart in 1970 and 2016. We observed that 45% of the microbial species were retained over the 45 year interval. Moreover, components of Apple’s microbiome associated with the allele frequency at seven SNPs in his genome. Collectively, our results are consistent with a genetic component contributing to the selection and maintenance of core members within the artist’s microbiome over his life-time.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Human Microbiome Journal Medicine-Infectious Diseases

自引率

0.00%

发文量

期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.

在比利苹果®的生命中，肠道微生物群的长期稳定性超过46 年

摘要

在比利苹果®的生命中，肠道微生物群的长期稳定性超过46 年