吡唑作为抗微生物支架:综述

IF 1.9 4区化学 Q2 CHEMISTRY, ORGANIC

Mini-reviews in Organic Chemistry Pub Date : 2022-10-31 DOI:10.2174/1570193x20666221031100542

P. Kaur, V. Arora

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引用次数: 0

摘要

严重和致命的传染病是由病原微生物引起的。在过去的几十年里，已经开发了许多抗微生物剂来治疗这些传染病，但这些药物仍在世界范围内扩展。此外，微生物正在对市售药物产生耐药性。因此，抗菌素耐药性正在扩大，成为最严重的健康威胁，特别是在发展中国家，因为抗微生物药物更容易获得。因此，有效抗生素的短缺表明对新型抗微生物药物的迫切需求。杂环化合物以其显著的结构特点，成为现代药物发现的核心。吡唑被认为是现代药物开发中重要的杂环核。本文综述了近十年来吡唑衍生物的抗菌作用及其对接研究，以期对从事抗菌药物开发的药物化学家有所帮助。

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Pyrazole as an anti-microbial scaffold: A comprehensive review

Serious and lethal infectious diseases are caused by pathogenic microorganisms. Numerous anti-microbial agents have been developed during last few decades for treating these infectious diseases, but these are still expanding worldwide over. Moreover, microorganisms are developing resistance against commercially available medicines. So, antimicrobial resistance is expanding as the most serious health threat particularly in developing countries due to easier availability of anti-microbial drugs. So, scarcity of effective antibiotics is suggesting the pressing demand of new anti-microbial agents. Modern drug discovery regarded heterocyclic compounds as its heart due to their striking structural characteristics. Pyrazole is considered as significant heterocyclic nucleus in modern drug development. This review brings a considerable summary regarding derivatives of pyrazole developed over last decade for their anti-microbial action along with docking studies carrying an expectation that it will be beneficial for medicinal chemists working in anti-microbial drug development.

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来源期刊

Mini-reviews in Organic Chemistry 化学-有机化学

CiteScore

4.50

自引率

4.30%

发文量

116

审稿时长

>12 weeks

期刊介绍： Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry