{"title":"特应性和过敏性疾病中宿主-微生物组的相互作用","authors":"Nanna Fyhrquist , Paulina Werner , Harri Alenius","doi":"10.1016/j.cotox.2023.100420","DOIUrl":null,"url":null,"abstract":"<div><p>The environmental exposome impacts the human microbiome, which in turn influences various immune and metabolic functions. Microbiome dysbiosis can be triggered by exposome components and may lead to the development of atopies or exacerbation of existing allergic conditions via the disruption of epithelial barriers and alteration of immune responses. The gut microbiome is a key regulator of the immune system, and immune homeostasis is maintained through bidirectional communication between the gut and distant tissues and organs. The skin microbiome also plays a central role in tuning host immunity and may contribute significantly to the emergence and progression of allergic skin disease. The loss of balance between the host and its microbiota can lead to the breakdown of immune tolerance and may thus contribute to allergy development. In this review, we discuss the current understanding of host-microbe and environmental interactions which have been linked with atopy and allergic diseases.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"35 ","pages":"Article 100420"},"PeriodicalIF":6.1000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Host-microbiome interactions in atopic and allergic diseases\",\"authors\":\"Nanna Fyhrquist , Paulina Werner , Harri Alenius\",\"doi\":\"10.1016/j.cotox.2023.100420\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The environmental exposome impacts the human microbiome, which in turn influences various immune and metabolic functions. Microbiome dysbiosis can be triggered by exposome components and may lead to the development of atopies or exacerbation of existing allergic conditions via the disruption of epithelial barriers and alteration of immune responses. The gut microbiome is a key regulator of the immune system, and immune homeostasis is maintained through bidirectional communication between the gut and distant tissues and organs. The skin microbiome also plays a central role in tuning host immunity and may contribute significantly to the emergence and progression of allergic skin disease. The loss of balance between the host and its microbiota can lead to the breakdown of immune tolerance and may thus contribute to allergy development. In this review, we discuss the current understanding of host-microbe and environmental interactions which have been linked with atopy and allergic diseases.</p></div>\",\"PeriodicalId\":37736,\"journal\":{\"name\":\"Current Opinion in Toxicology\",\"volume\":\"35 \",\"pages\":\"Article 100420\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468202023000359\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202023000359","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Host-microbiome interactions in atopic and allergic diseases
The environmental exposome impacts the human microbiome, which in turn influences various immune and metabolic functions. Microbiome dysbiosis can be triggered by exposome components and may lead to the development of atopies or exacerbation of existing allergic conditions via the disruption of epithelial barriers and alteration of immune responses. The gut microbiome is a key regulator of the immune system, and immune homeostasis is maintained through bidirectional communication between the gut and distant tissues and organs. The skin microbiome also plays a central role in tuning host immunity and may contribute significantly to the emergence and progression of allergic skin disease. The loss of balance between the host and its microbiota can lead to the breakdown of immune tolerance and may thus contribute to allergy development. In this review, we discuss the current understanding of host-microbe and environmental interactions which have been linked with atopy and allergic diseases.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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