对乙酰氨基酚在降低横纹肌溶解所致肾损伤风险中的作用:一项叙述性综述

Asia Pacific Journal of Medical Toxicology Pub Date : 2019-06-01 DOI:10.22038/APJMT.2019.13177

marjan emzhik, Pouran Makhdoumi, Nasrin Milani, Bita Dadpour

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引用次数: 2

摘要

背景：横纹肌溶解症是一种临床综合征，其结果是将受损肌肉细胞中的肌红蛋白释放到循环中，并经常导致急性肾损伤（1）。不同的机制被认为是横纹肌溶解症和肾功能衰竭的原因。然而，自由基的产生是导致肾损伤的最重要机制。因此，研究了各种抗氧化剂的作用。对乙酰氨基酚在治疗剂量下具有抗氧化能力，对肌肉损伤后的肾脏具有相当大的保护作用。研究表明，对乙酰氨基酚能增强肾功能，减少肾损伤，减少氧化剂损伤。本综述的目的是总结已证实的肾损伤病因证据以及对乙酰氨基酚减轻肾损伤的能力。方法：本综述涵盖了2010年至2017年发表在PubMed和Google Scholar上的文章。研究自由基在横纹肌病后肾损伤中作用的文章使用关键词横纹肌溶解症、肾脏和氧化应激进行搜索。用来查找关于对乙酰氨基酚抗氧化能力的文章的关键词是抗氧化剂和对乙酰氨基苯酚。结论：通过对乙酰氨基酚抗氧化能力和横纹肌溶解症肾功能衰竭机制的评价，该药可用于预防和治疗肾损伤，尤其是横纹肌溶解后的肾损伤。

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Role of acetaminophen in reducing risk of kidney injury from Rhabdomyolysis: A Narrative Review

Background: Rhabdomyolysis is a clinical syndrome that results in releasing myoglobin content from damaged muscle cells into circulation and often causes acute kidney injury (1). Different mechanisms are considered to be responsible in rhabdomyolysis and renal failure. However, free radical generation is the most important mechanism resulting in kidney injury. Thus, the effect of various antioxidants has been investigated. Acetaminophen, with antioxidant ability in therapeutic dose, has shown a considerable protective effect on kidney after muscle injury. The investigations have shown that acetaminophen enhances renal function, decreases renal damage and reduces oxidant injury. The aim of this review was to summarize proven evidences for etiology to renal injury and abilities of acetaminophen in reducing it. Methods: Articles published from 2010 to 2017 in PubMed and Google Scholar were covered in this review. The articles investigating the role of free radical in renal injury following Rhabdomylosis were searched using the keywords Rhabdomyolysis, kidney and oxidative stress. The keywords used to find articles regarding antioxidant ability of acetaminophen were antioxidant and acetaminophen. Conclusion: With assessment of evidences form antioxidant capacity of acetaminophen and mechanism of renal failure in Rhabdomyolysis, this drug can be useful for prevention and treatment of kidney injury especially following rhabdomyolysis.

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来源期刊

Asia Pacific Journal of Medical Toxicology

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Asia Pacific Journal of Medical Toxicology (APJMT) aims to expand the knowledge of medical toxicology and tries to provide reliable information in this field for medical and healthcare professionals. APJMT mainly focuses on research related to medical toxicology issues in the Asia Pacific region and publishes articles on clinical and epidemiological aspects of toxicology, poisonings emergency care, addiction, drug interactions and adverse effects. The journal accepts and welcomes high quality papers in the form of original articles and rarely review articles, case reports and scientific letters relevant to medical practice in toxicology.