糖尿病视网膜病变中长链非编码RNA INK4基因座反义非编码RNA的研究现状

Q4 Medicine

中华眼底病杂志 Pub Date : 2020-01-25 DOI:10.3760/CMA.J.ISSN.1005-1015.2020.01.019

ShuZe Chen, Zhengtong Yu, Zihong Wang, Xiaoqian Liang, Huimin Zhong, Min Fu

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引用次数: 0

摘要

糖尿病视网膜病变（DR）的发病机制复杂。长链非编码RNA（lncRNA）INK4基因座的反义非编码RNA与细胞增殖、分化和个体发育密切相关。它在视网膜血管内皮细胞发育不良中起着重要作用，是DR发病机制研究的一个新领域。根据目前的研究，ANRIL可能通过核因子-κB和ROS/聚腺苷酸二磷酸核糖聚合酶的信号通路在DR的发生和发展中发挥作用，并与p300、miR-200b、，和EZH2调节VEGF的表达和功能。特异性阻断ANRIL及其相关通路可能成为DR治疗的新靶点。关键词：糖尿病视网膜病变；评审；长链非编码RNA；ink4基因座中的反义非编码RNA

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Research status of antisense non-coding RNA in INK4 locus in long-chain non-coding RNA in diabetic retinopathy

The pathogenesis of diabetic retinopathy (DR) is complex. Antisense non-coding RNA (ANRIL) in the INK4 locus in long-chain non-coding RNA (lncRNA) is closely related to cell proliferation, differentiation, and individual development. It plays an important role in the dysplasia of retinal vascular endothelial cells and is a new field in the study of the pathogenesis of DR. According to the researches at present, ANRIL may plays its role in the occurrence and development of DR through the signal pathway of nuclear factor-κB and ROS/polyadenylation diphosphate ribose polymerase, and interact with p300, miR-200b, and EZH2 to regulating the expression and function of VEGF. Specific blocking ANRIL and its related pathways may become a new target in the treatment of DR. Key words: Diabetic retinopathy; Review; Long-chain non-coding RNA; Antisense non-coding RNA in the ink4 locus

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).