{"title":"5年来在m<s:1> xico总医院\" Eduardo Liceaga医生\"的膜性增生性肾小球肾炎患病率","authors":"C.A. Mendoza-Cerpa , M.V. Soto-Abraham","doi":"10.1016/j.hgmx.2017.05.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Membranoproliferative glomerulonephritis is a pattern of glomerular lesion with a variety of causes. It can be classified by using direct immunofluorescence into immune complex-mediated membranoproliferative glomerulonephritis and complement-mediated membranoproliferative glomerulonephritis.</p></div><div><h3>Objective</h3><p>Determine the prevalence of membranoproliferative glomerulonephritis by biopsy (light microscopy, direct immunofluorescence and electron microscopy), categorise them according to the most recent classification, identify possible causes and determine certain epidemiological and clinical characteristics.</p></div><div><h3>Material and method</h3><p>A descriptive, cross-sectional study was carried out, selecting renal biopsies with a membranoproliferative pattern at 5 years at Hospital General de México. Age, gender, clinical syndrome and immunofluorescence and electron microscopy results were obtained. Biopsies lacking immunofluorescence or electron microscopy results were excluded.</p></div><div><h3>Results</h3><p>133 biopsies diagnosed as membranoproliferative glomerulonephritis were obtained. The average annual rate was 3.37%, while average age was 31.35<!--> <!-->±<!--> <!-->16 years. The disorder affected mostly women (60.15%, <em>n</em> <!-->=<!--> <!-->80). Nephrotic syndrome was the most common clinical presentation (48.12%, <em>n</em> <!-->=<!--> <!-->64), while autoimmune disease was the most common cause (77.77%, <em>n</em> <!-->=<!--> <!-->91).</p></div><div><h3>Conclusions</h3><p>Direct immunofluorescence is indispensable for classifying membranoproliferative glomerulonephritis.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"80 4","pages":"Pages 197-203"},"PeriodicalIF":0.0000,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2017.05.008","citationCount":"0","resultStr":"{\"title\":\"Prevalence of membranoproliferative glomerulonephritis at Hospital General de México “Dr. Eduardo Liceaga” over a 5-year period\",\"authors\":\"C.A. Mendoza-Cerpa , M.V. Soto-Abraham\",\"doi\":\"10.1016/j.hgmx.2017.05.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Membranoproliferative glomerulonephritis is a pattern of glomerular lesion with a variety of causes. It can be classified by using direct immunofluorescence into immune complex-mediated membranoproliferative glomerulonephritis and complement-mediated membranoproliferative glomerulonephritis.</p></div><div><h3>Objective</h3><p>Determine the prevalence of membranoproliferative glomerulonephritis by biopsy (light microscopy, direct immunofluorescence and electron microscopy), categorise them according to the most recent classification, identify possible causes and determine certain epidemiological and clinical characteristics.</p></div><div><h3>Material and method</h3><p>A descriptive, cross-sectional study was carried out, selecting renal biopsies with a membranoproliferative pattern at 5 years at Hospital General de México. Age, gender, clinical syndrome and immunofluorescence and electron microscopy results were obtained. Biopsies lacking immunofluorescence or electron microscopy results were excluded.</p></div><div><h3>Results</h3><p>133 biopsies diagnosed as membranoproliferative glomerulonephritis were obtained. The average annual rate was 3.37%, while average age was 31.35<!--> <!-->±<!--> <!-->16 years. The disorder affected mostly women (60.15%, <em>n</em> <!-->=<!--> <!-->80). Nephrotic syndrome was the most common clinical presentation (48.12%, <em>n</em> <!-->=<!--> <!-->64), while autoimmune disease was the most common cause (77.77%, <em>n</em> <!-->=<!--> <!-->91).</p></div><div><h3>Conclusions</h3><p>Direct immunofluorescence is indispensable for classifying membranoproliferative glomerulonephritis.</p></div>\",\"PeriodicalId\":31559,\"journal\":{\"name\":\"Revista Medica del Hospital General de Mexico\",\"volume\":\"80 4\",\"pages\":\"Pages 197-203\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.hgmx.2017.05.008\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Medica del Hospital General de Mexico\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0185106317300537\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Medica del Hospital General de Mexico","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0185106317300537","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prevalence of membranoproliferative glomerulonephritis at Hospital General de México “Dr. Eduardo Liceaga” over a 5-year period
Background
Membranoproliferative glomerulonephritis is a pattern of glomerular lesion with a variety of causes. It can be classified by using direct immunofluorescence into immune complex-mediated membranoproliferative glomerulonephritis and complement-mediated membranoproliferative glomerulonephritis.
Objective
Determine the prevalence of membranoproliferative glomerulonephritis by biopsy (light microscopy, direct immunofluorescence and electron microscopy), categorise them according to the most recent classification, identify possible causes and determine certain epidemiological and clinical characteristics.
Material and method
A descriptive, cross-sectional study was carried out, selecting renal biopsies with a membranoproliferative pattern at 5 years at Hospital General de México. Age, gender, clinical syndrome and immunofluorescence and electron microscopy results were obtained. Biopsies lacking immunofluorescence or electron microscopy results were excluded.
Results
133 biopsies diagnosed as membranoproliferative glomerulonephritis were obtained. The average annual rate was 3.37%, while average age was 31.35 ± 16 years. The disorder affected mostly women (60.15%, n = 80). Nephrotic syndrome was the most common clinical presentation (48.12%, n = 64), while autoimmune disease was the most common cause (77.77%, n = 91).
Conclusions
Direct immunofluorescence is indispensable for classifying membranoproliferative glomerulonephritis.
期刊介绍：
The Medical Journal of the Hospital General de Mexico is the official organ of the Medical Society of the Hospital General de Mexico. The journal accepts articles in Spanish or in English on the field of hospital medicine. The journal publishes original articles, clinical cases, reviews articles, history notes, issues on medical education, short communications and editorials at the invitation of the Society. All articles are double blind peer reviewed by at least 2 reviewers and finally classified as accepted or rejected by the Editorial Board.
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