印度班加罗尔一家三级护理教学医院皮肤科皮质类固醇使用模式的前瞻性研究

Q3 Pharmacology, Toxicology and Pharmaceutics
Mehrangiz Nikzad, Sharath Kumar
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引用次数: 0

摘要

皮质类固醇在皮肤科被广泛使用,合理的处方可以带来最大的益处和最小的不良反应。本研究的目的是评估各种皮肤病的皮质类固醇处方模式,并识别、监测和评估任何药物相互作用和不良反应(如果有)。对一家三级护理教学医院皮肤科205例住院病例进行了为期6个月的皮质类固醇使用模式的前瞻性横断面研究。收集的数据涉及人口统计、病史和用药史、实验室数据以及住院期间和出院时开具的药物。进行描述性统计分析,以数量和百分比报告调查结果。129例患者服用皮质类固醇,其中男性患者72例,51-60岁年龄组最多,女性患者57例,31-40岁年龄组28%。常见的适应症是银屑病、皮炎和天疱疮。最常见的处方是泼尼松(27.4%),其次是氯倍他索(22.04%)。48.6%为局部治疗,28.2%为口服治疗,23.03%为肠外治疗。出院时主要使用泼尼松和氯倍他索,局部给药是最优选的给药途径。观察到倍他米松、曲安奈德、地塞米松和泼尼松等药物的相互作用,但没有不良反应报告。由于可以广泛选择皮质类固醇和剂型来治疗皮肤病,合理的治疗应该考虑药物的适当选择、效力、有效性和成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Prospective Study On Corticosteroids Utilization Pattern In Dermatology Department Of A Tertiary Care Teaching Hospital, Bangalore, India
Corticosteroids are widely prescribed in dermatology department and a rational prescribing lead to maximum benefit and minimum untoward effects. The objectives of this study were to assess the corticosteroid prescribing pattern for various skin diseases and to identify, monitor and assess any drug interactions and adverse reactions if any associated with their use. A prospective cross-sectional study on corticosteroid utilization pattern in dermatology department of a tertiary care teaching hospital was done by reviewing 205 inpatient cases for a period of 6 months. The data was collected with respect to demographics, medical and medication history, laboratory data and drugs prescribed during hospitalization and at discharge. A descriptive statistical analysis was performed to report the findings in terms of number and percentage. Corticosteroids were prescribed in 129 cases with 72male patients most in 51-60-year age group and 57female patients with 28% in 31-40-year age group. The common indications were psoriasis, dermatitis, and pemphigus. Prednisolone (27.4%) followed by clobetasol (22.04%) were most commonly prescribed. 48.6% therapy was by topical route, 28.2% by oral and 23.03% parenteral route. At discharge prednisolone and clobetasol were mostly prescribed and topical route was the most preferred route. Drug interactions involving drugs like betamethasone, triamcinolone, dexamethasone, and prednisolone were observed but no adverse reactions were reported. With a wide choice of corticosteroids and dosage forms available to treat dermatological conditions the rational therapy should consider the appropriate choice of drugs, potency, effectiveness and the cost.
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