对退行性关节病理的影响

Q4 Medicine
A. Stănescu, Marius Donici, I. Grăjdeanu, A. Simionescu
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引用次数: 0

摘要

改善老年人口的健康是一个复杂的目标,需要多因素的方法和对致病因素的了解。骨关节炎是最常见的关节疾病,也是50岁以上人群致残的第二大原因,它具有重大的经济影响,并成为一个真正的社会和公共卫生问题。尽管在不到30%的老年人群中出现,但关节软骨的病理改变在65岁以上的所有死亡中都有发现。这就是为什么我们认为初级预防是该疾病的一个重要目标。这篇综述介绍的病因包括遗传易感性、年龄、体重指数、性别、骨密度和关节软骨的致病性退化。这包括两个方面的进化,关节软骨的逐渐退化和软骨下骨的修复反应。总之,了解这些机制是处理退行性关节病理的第一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influences in degenerative joint pathology
Improving the aged population’s health is a complex goal that requires a multifactorial approach and the knowledge of etiopathogenic factors. Osteoarthritis is the most common joint disease and the second leading cause of disability in people over the age of 50, which has a substantial economic impact and turns into a real social and public health problem. Although it manifested in less than 30% of the older population, pathological changes in the articular cartilage are founded in all deaths over 65 years. That is why we consider primary prophylaxis an important goal for the disease. This minireview presents etiological factors as genetic predisposition, age, body mass index, sex, bone density and the pathogenic degradation of articular cartilage. This includes two aspects of evolution, the progressive degradation of the articular cartilage and the reparative reaction of the subchondral bone. In conclusion, knowing these mechanisms are the first step in managing degenerative joint pathology.
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CiteScore
0.10
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0.00%
发文量
22
审稿时长
4 weeks
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