PYGO2（pygopus家族PHD手指2）

Q4 Medicine

Atlas of Genetics and Cytogenetics in Oncology and Haematology Pub Date : 2020-02-01 DOI:10.4267/2042/70695

I. Esposito, A. Cassaro

{"title":"PYGO2（pygopus家族PHD手指2）","authors":"I. Esposito, A. Cassaro","doi":"10.4267/2042/70695","DOIUrl":null,"url":null,"abstract":"PYGO2 is member of a conserved family of plant homeo domain (PHD)-containing proteins and takes part in a wide range of developmental and transcriptional processes. The most relevant role played by PYGO2 is in Wnt signaling pathway, where it is required for βcatenin/TCF-dependent transcription, even if it has showed to have a crucial role also in absence of βcatenin in tissues such as eye and testis. PYGO2 is also known as a chromatin effector because of its implication in chromatin remodelling processes through regulation of histones methylation.","PeriodicalId":52212,"journal":{"name":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PYGO2 (pygopus family PHD finger 2)\",\"authors\":\"I. Esposito, A. Cassaro\",\"doi\":\"10.4267/2042/70695\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"PYGO2 is member of a conserved family of plant homeo domain (PHD)-containing proteins and takes part in a wide range of developmental and transcriptional processes. The most relevant role played by PYGO2 is in Wnt signaling pathway, where it is required for βcatenin/TCF-dependent transcription, even if it has showed to have a crucial role also in absence of βcatenin in tissues such as eye and testis. PYGO2 is also known as a chromatin effector because of its implication in chromatin remodelling processes through regulation of histones methylation.\",\"PeriodicalId\":52212,\"journal\":{\"name\":\"Atlas of Genetics and Cytogenetics in Oncology and Haematology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Atlas of Genetics and Cytogenetics in Oncology and Haematology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4267/2042/70695\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Atlas of Genetics and Cytogenetics in Oncology and Haematology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4267/2042/70695","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

PYGO2是一个含有植物同源结构域（PHD）的保守蛋白家族的成员，参与广泛的发育和转录过程。PYGO2发挥的最相关作用是在Wnt信号通路中，它是β连环蛋白/TCF依赖性转录所必需的，即使它在眼睛和睾丸等组织中缺乏β连环蛋白的情况下也显示出关键作用。PYGO2也被称为染色质效应子，因为它通过调节组蛋白甲基化参与染色质重塑过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

PYGO2 (pygopus family PHD finger 2)

PYGO2 is member of a conserved family of plant homeo domain (PHD)-containing proteins and takes part in a wide range of developmental and transcriptional processes. The most relevant role played by PYGO2 is in Wnt signaling pathway, where it is required for βcatenin/TCF-dependent transcription, even if it has showed to have a crucial role also in absence of βcatenin in tissues such as eye and testis. PYGO2 is also known as a chromatin effector because of its implication in chromatin remodelling processes through regulation of histones methylation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Atlas of Genetics and Cytogenetics in Oncology and Haematology Medicine-Oncology

自引率

0.00%

发文量