{"title":"流化床造粒法制备硫酸特布他林速释片的设计与评价","authors":"S. Bhattacharyya, M. Rb","doi":"10.5530/ctbp.2020.2.16","DOIUrl":null,"url":null,"abstract":"Materials and methods:The process of granulation by fluidized bed granulation technology was used to prepare eight formulations (F1-F8) using various concentrations of binders PVP K30, PVP K-90 and disintegrants microcrystalline cellulose, sodium starch glycolate.The granules were evaluated for preformulation parameters like bulk density, tapped density, Carr ’s compressibility index, and hausner ratio, angle of repose, loss on drying, and sieve analysis. The compressed tablets were evaluated for post compression parameters like thickness, hardness, weight variation, friability, disintegration, drug content, content uniformity and dissolution. The stability studies were performed for a period of 3 months at 30oC/75%RH & 40oC/75%RH.","PeriodicalId":10980,"journal":{"name":"Current Trends in Biotechnology and Pharmacy","volume":"14 1","pages":"156-163"},"PeriodicalIF":0.0000,"publicationDate":"2020-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Design and evaluation of terbutaline sulphate immediate release tablets prepared by fluidized bed granulation technology\",\"authors\":\"S. Bhattacharyya, M. Rb\",\"doi\":\"10.5530/ctbp.2020.2.16\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Materials and methods:The process of granulation by fluidized bed granulation technology was used to prepare eight formulations (F1-F8) using various concentrations of binders PVP K30, PVP K-90 and disintegrants microcrystalline cellulose, sodium starch glycolate.The granules were evaluated for preformulation parameters like bulk density, tapped density, Carr ’s compressibility index, and hausner ratio, angle of repose, loss on drying, and sieve analysis. The compressed tablets were evaluated for post compression parameters like thickness, hardness, weight variation, friability, disintegration, drug content, content uniformity and dissolution. The stability studies were performed for a period of 3 months at 30oC/75%RH & 40oC/75%RH.\",\"PeriodicalId\":10980,\"journal\":{\"name\":\"Current Trends in Biotechnology and Pharmacy\",\"volume\":\"14 1\",\"pages\":\"156-163\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Trends in Biotechnology and Pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5530/ctbp.2020.2.16\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Trends in Biotechnology and Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/ctbp.2020.2.16","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Design and evaluation of terbutaline sulphate immediate release tablets prepared by fluidized bed granulation technology
Materials and methods:The process of granulation by fluidized bed granulation technology was used to prepare eight formulations (F1-F8) using various concentrations of binders PVP K30, PVP K-90 and disintegrants microcrystalline cellulose, sodium starch glycolate.The granules were evaluated for preformulation parameters like bulk density, tapped density, Carr ’s compressibility index, and hausner ratio, angle of repose, loss on drying, and sieve analysis. The compressed tablets were evaluated for post compression parameters like thickness, hardness, weight variation, friability, disintegration, drug content, content uniformity and dissolution. The stability studies were performed for a period of 3 months at 30oC/75%RH & 40oC/75%RH.
期刊介绍:
The Association of Biotechnology and Pharmacy (ABAP) will be useful to form a forum for scientists so that they can bring together to discuss and find scientific solutions to the problems of society. The annual meetings will help the members to share their knowledge and publish their research knowledge particularly by members and fellows of the Association and special care will be taken to provide an opportunity for young scientists. Besides this the association is planned to organize symposia, seminars and workshops on current developments of Biotechnology and Pharmacy particularly on the subject of current scientific interest, and the proceedings of which will be published regularly. And in view of the vast development of science and to disseminate the problems in publication of research work, an international journal of Current Trends in Biotechnology and Pharmacy has been started by ABAP.