百草枯致血栓性微血管病：百草枯超急性中毒死亡的病理生理学

IF 0.2 4区医学 Q4 MEDICINE, GENERAL & INTERNAL

West Indian Medical Journal Pub Date : 2018-12-27 DOI:10.7727/WIMJ.2018.141

H. Daisley, A. Rampersad, O. Acco, D. Meyers

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引用次数: 0

摘要

本文描述了摄入百草枯后24小时内死亡的患者因百草枯中毒而自杀的病理生理学。这些死亡被称为超急性百草枯中毒死亡。血栓性微血管病变是所有这些病例的主要病理发现，在脑、肺、心、肾和所有检查的器官和组织中都很明显。值得注意的是，发生弥散性肺泡毛细血管血栓形成，造成肺泡壁损伤，包括胸膜下肺泡壁损伤，导致局灶性内脏性胸膜破裂，导致气胸和纵隔气肿，从而引起百草枯毒性气胸和纵隔气肿的另一种机制。血栓性微血管病变是百草枯中毒的主要病理机制，迄今尚未见报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Paraquat-induced Thrombotic Microangiopathy: The Pathophysiology in Hyperacute Paraquat Poisoning Deaths

This paper described the pathophysiology of suicide deaths from paraquat poisoning which occurred in patients who died in fewer than 24 hours after ingesting paraquat. These deaths were referred to as hyperacute paraquat poisoning deaths. Thrombotic microangiopathy was the predominant pathological finding in all these cases and was evident in the brain, lung, heart, kidneys and in all organs and tissues examined. Of note, diffuse alveolar capillary thrombosis occurred, causing damage to alveolar walls, including those in subpleural locations, resulting in focal visceral pleural rupture leading to pneumothorax and pneumomediastinum in these cases, thus giving rise to yet another mechanism of pneumothorax and pneumomediastinum in paraquat toxicity. Thrombotic microangiopathy is the major pathological mechanism that underlies paraquat poisoning and has not hitherto been reported.

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来源期刊

West Indian Medical Journal 医学-医学：内科

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal is international in scope, with author and editorial contributions from across the globe. The focus is on clinical and epidemiological aspects of tropical and infectious diseases, new and re-emerging infections, chronic non-communicable diseases, and medical conditions prevalent in the Latin America-Caribbean region, and of significance to global health, especially in developing countries. The Journal covers all medical disciplines, as well as basic and translational research elucidating the pathophysiologic basis of diseases or focussing on new therapeutic approaches, and publishes original scientific research, reviews, case reports, brief communications, letters, commentaries and medical images. The Journal publishes four to six issues and four supplements annually. English is the language of publication but Abstracts are also duplicated in Spanish. Most of the articles are submitted at the authors’ initiative, but some are solicited by the Editor-in-Chief. Unless expressly stated, the Editorial Board does not accept responsibility for authors’ opinions. All papers on submission are reviewed by a subcommittee. Those deemed worthy for review are sent to two or three reviewers (one of the three might be a statistician if necessary). The returned papers with reviewer comments are reviewed by the Editor-in-Chief. Papers may be rejected, accepted or sent back to authors for revision. Resubmitted papers from authors are reviewed by the Editor-in-Chief and may be sent back to reviewers or a final decision made by Editor-in-Chief. The decision of the Editorial Board is final with regards to rejected articles. Rejected articles will not be returned to the authors. The editorial subcommittee has the right to return sub-standard manuscripts to the authors, rather than passing them on to the reviewers. This implies outright rejection of the manuscript.