新冠肺炎严重程度与死亡率性别差异的病因思考

D. Shweiki
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引用次数: 0

摘要

新冠肺炎表现出性别偏见行为,男性的发病率和死亡率较高。从这个意义上说,新冠肺炎偏离了许多病毒感染的典型趋势,这些病毒感染的特点是男性的强度和流行率较高,但女性死亡率较高。新冠肺炎的严重程度和死亡率与几种潜在疾病有关,这些疾病表现出显著的自给自足的男性偏倚二态性,因此有时被假设是导致新冠肺炎死亡率平衡向较高男性死亡倾斜的原因。然而,类似的合并症在其他病毒感染中普遍存在,这引发了人们对新冠肺炎独特之处的好奇?答案可能在于肾素-血管紧张素系统和ACE2受体在新冠肺炎进展中的参与,这两个因素是导致新冠肺炎死亡的重要因素。性别之间RAS和ACE2的表达和功能存在明显的结构性差异,可能会使死亡率倾向于男性风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contemplating on the Etiology of COVID-19 Severity and Mortality Sex Differences
COVID-19 displays a sex-biased behavior with a higher rate of intensity and mortality in men. In that sense, COVID-19 deflects-off the typical trend of many viral infections which are characterized by a higher rate of intensity and prevalence in males, yet a higher female mortality rate. Severity and mortality rates of COVID-19 are associated with several underlying diseases, which exhibit significant self-sufficient male-biased dimorphism, thus are at times hypothesized to be the ones responsible to tilt mortality balance toward higher men death in COVID-19. Yet, similar comorbidities prevail in other viral infections, raising curiosity to what makes COVID-19 unique? The answer may lay in the involvement of renin-angiotensin system and ACE2 receptor in COVID-19 progression, 2 players which are significant contributors to the fatality of COVID-19. A structured difference is evident in the expression and function of RAS and ACE2 between the sexes, presumably tipping over mortality rate tendency toward male-risk factor.
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