TPGS/P84混合聚合物胶束的开发与优化：紫杉醇抗肿瘤的稳定性和抗癌作用的增强

IF 0.4 4区医学 Q4 PHARMACOLOGY & PHARMACY

Acta poloniae pharmaceutica Pub Date : 2023-05-04 DOI:10.32383/appdr/161587

Qi Huang, Yingli Zhao, Xing Fang, J. Liu, Quan Xia, Chao Tan, Yao Peng, Jingjing Wu

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引用次数: 0

摘要

混合胶束作为一种具有高度可调节性的新型靶向给药系统，在生物医学领域得到了广泛的研究。为了研究含有两种不同分子的混合物是否具有良好的靶向抗肿瘤作用，我们制备了基于D-α-生育酚聚乙二醇1000琥珀酸酯(TPGS)和三嵌段共聚物P84的mm，并观察了P84/TPGS mm的表征、细胞内吞和胞外分泌情况。选择经典抗肿瘤药物紫杉醇(Paclitaxel, PTX)作为模型化合物，探讨其体内抗肿瘤作用。结果表明，P84/TPGS mm具有较好的稳定性、粒径分布适宜、良好的细胞内吞作用和肿瘤球通透性，可提高肿瘤部位PTX的通透性，有效抑制小鼠H22肿瘤的生长。综上所述，P84/TPGS mm是一种潜在的靶向癌症的胶束载体系统，有待进一步研究。

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Development and optimization of TPGS/P84 mixed polymeric micelles: enhanced stability and anticancer effect of paclitaxel against tumor therapy

Mixed micelles (MMs), as a new targeted drug delivery system with high adjustability, have been widely studied in biomedicines. In order to study whether mixtures containing two different molecules have excellent targeted anti-tumor effect, MMs based on D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) and triblock copolymer P84 were prepared, and the characterization, cell endocytosis, and exocytosis of P84/TPGS MMs were observed. Paclitaxel (PTX), a classical anti-tumor drug, was selected as a model compound to explore its anti-tumor effect in vivo. The results showed that P84/TPGS MMs had better stability, suitably distributed particle size, good cell endocytosis, and tumor sphere permeability, which could improve the permeability of PTX in the tumor site and effectively inhibit the growth of H22 tumor in mice. In conclusion, P84/TPGS MMs is a potential micelle carrier system of cancer targeting, needing further investigation.

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来源期刊

Acta poloniae pharmaceutica 医学-药学

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.