Does Submucosal Placentrex® Injection Hasten the Soft Tissue Healing in Mandibular Third Molar Impaction Surgery? A Prospective Randomized Split-Mouth Study

Background: This study focused to evaluate the potency of injection Placentrex® by assessing the rate of soft tissue healing with bilateral symmetrical third molar impaction by using early wound healing score. Materials and Methods: The split mouth study included 23 patients with bilaterally symmetrical third molar impaction. Randomly one side was selected as study group and other side as control group. 2 ml of Placentrex® injection was administered submucosally before surgical removal on the buccal and retromolar region in study group while control group was allowed to heal naturally. Parameters like soft tissue healing, pain, trismus and swelling were assessed on 1st,3rd and 7th post operative days. Early healing score was used to assess the soft tissue healing after surgical removal. Results: The mean re-epithelialization based on CSR on 3rd post operative day showed characteristic significance with mean score of 4.56 (p<0.05) when compared to the control group which showed a mean score of 2.73. The inflammation based on CSI on 3rd postoperative day for the study group revealed a mean value of 1.73 (p<0.05) whereas for the control group a mean of 1.04 was recorded proving significance. It was found that there was no significant statistical difference in the case and control group in relevance to post operative pain, swelling and mouth opening. Conclusion: Placentrex® exhibited characteristic significance in early soft tissue healing with signs of less inflammation and early reepithelialisation.