{"title":"RET原癌基因种系突变与结直肠癌癌症和息肉的关系","authors":"R. Guy","doi":"10.19080/argh.2019.12.555835","DOIUrl":null,"url":null,"abstract":"The RET proto-oncogene is located on chromosome 10q11.2 and encodes a transmembrane receptor tyrosine kinase that has three unique isoforms [1]. Four ligands can bind and activate RET, leading to the aberrant activity of several signaling pathways including PI3K/Akt and MAPK pathway [2]. The aberrant expression of RET may function as an oncogene in certain solid tumor malignancies including papillary, medullary thyroid cancers and the multiple endocrine neoplasm type 2 (MEN2) syndrome [3,4].","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between Germline Mutations in the RET Proto-Oncogene and Colorectal Cancer and Polyps\",\"authors\":\"R. Guy\",\"doi\":\"10.19080/argh.2019.12.555835\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The RET proto-oncogene is located on chromosome 10q11.2 and encodes a transmembrane receptor tyrosine kinase that has three unique isoforms [1]. Four ligands can bind and activate RET, leading to the aberrant activity of several signaling pathways including PI3K/Akt and MAPK pathway [2]. The aberrant expression of RET may function as an oncogene in certain solid tumor malignancies including papillary, medullary thyroid cancers and the multiple endocrine neoplasm type 2 (MEN2) syndrome [3,4].\",\"PeriodicalId\":72074,\"journal\":{\"name\":\"Advanced research in gastroenterology & hepatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-02-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced research in gastroenterology & hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.19080/argh.2019.12.555835\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced research in gastroenterology & hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19080/argh.2019.12.555835","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association between Germline Mutations in the RET Proto-Oncogene and Colorectal Cancer and Polyps
The RET proto-oncogene is located on chromosome 10q11.2 and encodes a transmembrane receptor tyrosine kinase that has three unique isoforms [1]. Four ligands can bind and activate RET, leading to the aberrant activity of several signaling pathways including PI3K/Akt and MAPK pathway [2]. The aberrant expression of RET may function as an oncogene in certain solid tumor malignancies including papillary, medullary thyroid cancers and the multiple endocrine neoplasm type 2 (MEN2) syndrome [3,4].
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
