大麻类药物作为治疗疼痛的药物

IF 0.2 4区医学 Q4 MEDICINE, GENERAL & INTERNAL

West Indian Medical Journal Pub Date : 2017-10-26 DOI:10.7727/WIMJ.2017.192

C. McGaw

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引用次数: 0

摘要

目的：本文综述内源性大麻素系统在疼痛传递和调节中的作用。对天然和合成大麻素的各个方面进行了探索，以确定其在疼痛治疗和管理中的适用性。方法：对内源性大麻素系统和CBs的生理学进行单独综述，并与它们在治疗疼痛中的假设作用有关。结果：大麻类药物在慢性疼痛中的作用比急性疼痛更显著。抑制机制可能比直接激活大麻素受体更有效。许多真正的和合成的大麻介导的镇痛的临床试验都提供了负面或模棱两可的结果。结论：用大麻素受体激动剂或增强内源性大麻素功能的药物（通过增加内源性大麻肽的释放或减少其再吸收）制备的药物可能为以疼痛为主要症状的疾病提供所需的新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Cannabinoids as Therapeutic Agents in the Management of Pain

Objective: This review focussed on the role of the endocannabinoid system in relation to pain transmission and modulation. Various facets of both naturally occurring and synthetic cannabinoids (CBs) were explored in an effort to ascertain their suitability in the treatment and management of pain. Methods: The endocannabinoid system and the physiology of CBs were reviewed in isolation and in relation to their hypothesized role in treating pain. Results: Cannabinoids have a more significant effect in instances of chronic pain than acute pain. Inhibitory mechanisms may be more effective than direct activation of the cannabinoid receptors. Many clinical trials of both genuine and synthetic cannabis-mediated analgesia have provided negative or equivocal results. Conclusion: Medications prepared with cannabinoid receptor agonists or with drugs that enhance endocannabinoid function (by either increasing release or diminishing reuptake of endocannabinoids) may afford the novel therapeutic approaches demanded by disorders in which pain is a prominent symptom.

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来源期刊

West Indian Medical Journal 医学-医学：内科

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal is international in scope, with author and editorial contributions from across the globe. The focus is on clinical and epidemiological aspects of tropical and infectious diseases, new and re-emerging infections, chronic non-communicable diseases, and medical conditions prevalent in the Latin America-Caribbean region, and of significance to global health, especially in developing countries. The Journal covers all medical disciplines, as well as basic and translational research elucidating the pathophysiologic basis of diseases or focussing on new therapeutic approaches, and publishes original scientific research, reviews, case reports, brief communications, letters, commentaries and medical images. The Journal publishes four to six issues and four supplements annually. English is the language of publication but Abstracts are also duplicated in Spanish. Most of the articles are submitted at the authors’ initiative, but some are solicited by the Editor-in-Chief. Unless expressly stated, the Editorial Board does not accept responsibility for authors’ opinions. All papers on submission are reviewed by a subcommittee. Those deemed worthy for review are sent to two or three reviewers (one of the three might be a statistician if necessary). The returned papers with reviewer comments are reviewed by the Editor-in-Chief. Papers may be rejected, accepted or sent back to authors for revision. Resubmitted papers from authors are reviewed by the Editor-in-Chief and may be sent back to reviewers or a final decision made by Editor-in-Chief. The decision of the Editorial Board is final with regards to rejected articles. Rejected articles will not be returned to the authors. The editorial subcommittee has the right to return sub-standard manuscripts to the authors, rather than passing them on to the reviewers. This implies outright rejection of the manuscript.