与在乌干达坎帕拉销售的一些草药产品的消费有关的黄曲霉毒素含量和健康风险

IF 0.4 Q4 CHEMISTRY, ANALYTICAL
Patrick Onen, James Watmon, Timothy Omara, Daniel Ocira
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引用次数: 2

摘要

说服性广告和夸大食用草药产品对健康的好处,以及“天然”是“安全”的心理画面,都促进了乌干达传统药物的使用。然而,草药产品可能不安全,因为它们可能被真菌毒素污染。在这项研究中,我们使用高效液相色谱-串联质谱法定量了在乌干达坎帕拉销售的Real Koff产品、Eddagala ly'e kifuba n'e senyiga、Omusujja、咳嗽混合物和发烧草药产品中黄曲霉毒素(B1、B2、G1和G2)的水平。使用危害指数法评估相关的消费健康风险。在60%的样本中仅检测到黄曲霉毒素B1,其中40%的样本超过了世界卫生组织≤5微克/公斤的指导方针。危害指数均小于1,这意味着严重依赖草药产品的乌干达人暴露于亚致死剂量的黄曲霉毒素,从长远来看可能会导致慢性影响。使用更大样本量的研究应该评估当前观察是常规发生还是偶发事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aflatoxin content and health risks associated with consumption of some herbal products sold in Kampala, Uganda
Persuasive adverts and exaggeration of health benefits from consumption of herbal products as well as the mental picture of ‘natural’ is ‘safe’ has boosted traditional medicine use in Uganda. However, herbal products may be unsafe due to the possibility of their contamination with mycotoxins. In this study, we quantified the levels of aflatoxins (B1, B2, G1 and G2) in Real Koff product, Eddagala ly’e kifuba n’e senyiga, Omusujja, Cough mixture and Fever herbal products sold in Kampala, Uganda using high performance liquid chromatography-tandem mass spectrometry. The associated consumption health risks were assessed using the hazard index method. Only aflatoxin B1 was detected in 60% of the samples, with 40% of these surpassing WHO guidelines of ≤ 5 µg/kg. The hazard indices were all less than 1, implying that Ugandans who heavily rely on the herbal products are exposed to aflatoxins at sublethal doses which may lead to chronic effects in the long run. Studies using a larger sample size should assess whether the current observation is a routine occurrence or a sporadic event.
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来源期刊
French-Ukrainian Journal of Chemistry
French-Ukrainian Journal of Chemistry CHEMISTRY, ANALYTICAL-
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审稿时长
4 weeks
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