补体在输血后溶血和高溶血反应中的作用。

IF 2.7 2区 医学 Q2 HEMATOLOGY
Lubka T. Roumenina , Pablo Bartolucci , France Pirenne
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引用次数: 14

摘要

输血相关溶血通常是受体产生的抗体与供体红细胞携带的血型抗原相互作用的结果。这种反应可能危及生命,特别是镰状细胞患者,当他们出现高溶血并伴随自身红细胞的加速清除时。补体系统是输血后溶血病理生理的关键参与者。补体可以引发溶血反应,放大炎症反应,增加组织损伤。在镰状细胞病中,补体可通过经典途径激活,但也可通过替代途径激活。慢性溶血性贫血镰状细胞患者永久释放的溶血衍生产物可能影响补体激活的效力。所有镰状细胞患者的观察以及体外实验和动物模型的体内数据都支持补体是输血相关溶血和高溶血的关键疾病驱动因素和有希望的治疗靶点的结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of Complement in Post-Transfusion Hemolysis and Hyperhemolysis Reaction

Transfusion-related hemolysis is classically the result of an interaction between antibodies produced by the recipient and blood group antigens carried by the donor red blood cells. This reaction may be life threatening, especially in sickle cell patients when they develop hyperhemolysis with concomitant accelerated clearance of their own red blood cells. The complement system is a key participant in the pathophysiology of post-transfusion hemolysis. Complement can trigger the hemolytic reaction, amplify the inflammatory response and increase tissue damage. Complement is activated by the classical pathway but may also be activated by the alternative pathway in sickle cell disease. The hemolysis-derived products permanently released by sickle cell patients with chronic hemolytic anemia may affect the potency of complement activation. All the observations in sickle cell patients as well as in vitro experiments and in vivo data in animal models support the conclusion that complement is key disease driver and a promising therapeutic target in the context of transfusion-related hemolysis and hyperhemolysis.

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来源期刊
Transfusion Medicine Reviews
Transfusion Medicine Reviews 医学-血液学
CiteScore
11.60
自引率
0.00%
发文量
40
审稿时长
21 days
期刊介绍: Transfusion Medicine Reviews provides an international forum in English for the publication of scholarly work devoted to the various sub-disciplines that comprise Transfusion Medicine including hemostasis and thrombosis and cellular therapies. The scope of the journal encompasses basic science, practical aspects, laboratory developments, clinical indications, and adverse effects.
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