小前庭神经鞘瘤的治疗

J. Whitaker, K. Almefty
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摘要

神经瘤是一种良性神经鞘肿瘤,起源于前庭神经(颅神经[CN]VIII)上下分支的施旺细胞。VS占桥小脑角肿瘤的80%,占颅内肿瘤的8%。VS的临床发病率为每100000人中有1例。MRI可用性的增加导致VS的发生率增加,诊断时平均肿瘤大小变小,诊断时基线听力状态改善。此外,最近的研究提高了我们对这些肿瘤自然史的理解。放射外科作为一种主要治疗方式的广泛应用已经取得了成果,显微外科技术也已经成熟。这些变量,以及各种可用治疗方案的成功和缺点,需要对VS患者的管理采取细致的方法,特别是那些局限于内耳道或最大尺寸小于1.5厘米的小肿瘤患者。小肿瘤的治疗模式侧重于神经功能的保留。VS患者的症状通常包括听力损失、耳鸣、眩晕和不稳定。尽管前庭功能障碍会导致严重残疾,但关于治疗方案中前庭结果的比较数据很少。大多数研究集中在肿瘤控制、面神经(CN VII)功能和听力结果上。最近的研究还包括生活质量调查。本文总结了显微外科、放射外科和观察这三种治疗方案的结果,并提出了一种针对小VS患者的治疗算法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of Small Vestibular Schwannomas
neuroma, is a benign nerve sheath tumor that arises from the Schwann cells of the superior and inferior branches of the vestibular nerve (cranial nerve [CN] VIII). VS accounts for 80% of cerebellopontine angle tumors and 8% of all intracranial tumors. VS has a clinical incidence of 1 case per 100,000 population. The increased availability of MRI has resulted in an increased incidence of VS, a smaller average tumor size at diagnosis, and an improved baseline hearing status at diagnosis. In addition, recent studies have improved our understanding of the natural history of these tumors. The results of the widespread application of radiosurgery as a primary treatment modality are becoming available, and the microsurgical technique has reached maturity. These variables, and the successes and shortcomings of the various available treatment options, require a nuanced approach to the management of patients with VS, particularly those with small tumors limited to the internal auditory meatus or less than 1.5 cm in greatest dimension. Treatment paradigms for small tumors are focused on the preservation of neurologic function. Presenting symptoms of patients with VS typically include hearing loss, tinnitus, vertigo, and unsteadiness. Although vestibular dysfunction can result in significant disability, comparative data are sparse regarding vestibular outcomes among treatment options. Most studies focus on tumor control, facial nerve (CN VII) function, and hearing outcomes. Recent studies have also included quality-of-life surveys. This article summarizes outcomes for the 3 management options of microsurgery, radiosurgery, and observation, and it suggests a management algorithm for patients with a small VS.
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