细菌性脑膜炎患者的危险因素和合并症

Q4 Medicine
P. Argirova, Y. Kalchev, M. Murdjeva, M. Stoycheva
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引用次数: 0

摘要

摘要介绍。细菌性脑膜炎是一种严重的疾病,死亡率高,神经系统后遗症多。它与多种危险因素有关。该研究的目的是确定与细菌性脑膜炎相关的主要危险因素,并概述细菌性脑膜炎患者慢性疾病的发病率及其与患者年龄和脑膜炎病因(如果有的话)的关系。材料和方法。该研究包括90名在Sv大学医院传染病诊所接受治疗的细菌性脑膜炎患者。在2016年1月1日至2019年9月30日期间,Georgi - Plovdiv。采用了流行病学分析、临床检查、实验室和微生物检测以及统计学方法。结果。共有76.8%的患者伴有心血管疾病(38.9%)、糖尿病(16.7%)、免疫抑制(16.7%)、肝脏疾病(11.1%)、肺部疾病(10%)、肿瘤(7.8%)、慢性肾脏疾病(7.8%)。成人免疫抑制(p = 0.009)、心血管疾病(p = 0.0001)和糖尿病(p = 0.009)的发生率明显高于儿童。37.8%的患者存在危险因素(儿童44%,成人35.4%,p >.05),特别是肺炎球菌性脑膜炎患者(47.1%)。主要危险因素为脑膜炎前3个月内的中耳炎或鼻窦炎(17.8%),其次为头部外伤(6.7%)、酒精中毒(6.2%)、脑膜炎复发(4.4%)、脑脊液鼻漏(3.3%)、普外科手术(3.3%)和脾切除术(2.2%)。结论。老年脑膜炎患者的合并症比儿童更常见,主要是心血管疾病、糖尿病和免疫抑制。慢性疾病的发病率最高的是李斯特菌性脑膜炎。在两个年龄组中都发现了危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk Factors and Comorbidity in Patients with Bacterial Meningitis
Abstract Introduction. Bacterial meningitis is a severe disease with high mortality and frequent residual neurological sequelae. It is associated with multiple risk factors. The aim of the study was to establish the main risk factors associated with bacterial meningitis and to outline the incidence of chronic diseases in patients with bacterial meningitis and their relationship to the patients’ age and etiology of meningitis, if any. Materials and methods. The study included 90 patients with bacterial meningitis admitted to the Clinic of Infectious Diseases, University Hospital “Sv. Georgi” – Plovdiv during the period January 1, 2016 – September 30, 2019. Epidemiological analyses, clinical examinations, laboratory and microbiological tests, and statistical methods were used. Results. A total of 76.8% of patients had concomitant conditions: cardiovascular diseases (38.9%), diabetes mellitus (16.7%), immunosuppression (16.7%), liver diseases (11.1%), pulmonary diseases (10%), neoplasms (7.8%), chronic kidney diseases (7.8%). The incidence of immunosuppression (p = 0.009), cardiovascular disease (p = 0.0001), and diabetes (p = 0.009) were significantly higher in adults compared to children. Risk factors were present in 37.8% of patients (44% in children and 35.4% in adults, p > 0.05), especially in patients with pneumococcal meningitis (47.1%). The main risk factor was otitis or sinusitis in the last 3 months before meningitis (17.8%), followed by head trauma (6.7%), alcoholism (6.2%), recurrent episode of meningitis (4.4%), nasal leakage of cerebrospinal fluid (3.3%), general surgery (3.3%), and splenectomy (2.2%). Conclusion. Elderly patients with meningitis had more frequent comorbidities than children, mostly cardiovascular diseases, diabetes, and immunosuppression. The highest incidence of chronic diseases was found in patients with listerial meningitis. Risk factors were found in both age groups.
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来源期刊
Acta Medica Bulgarica
Acta Medica Bulgarica Medicine-Medicine (all)
CiteScore
0.30
自引率
0.00%
发文量
33
审稿时长
25 weeks
期刊介绍: About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.
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