埃尔比勒市抗酸剂中和酸能力的比较

D. Boya, J. Ahmed
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引用次数: 1

摘要

背景与目的:抗酸剂是一种能中和盐酸、降低胃酸的碱性物质。它们是用于治疗消化不良的非处方药。最常用的抗酸剂是碳酸氢钠、氢氧化镁、氢氧化铝和碳酸钙。本研究旨在通过发现其中和酸能力来评估埃尔比勒市常用的抗酸剂的有效性。方法:酸中和量的测定方法参照药典。将抗酸剂溶解在过量的盐酸中,然后用氢氧化钠溶液反滴定中和过量的酸,制备样品。被抗酸剂中和的毫当量的数目就是抗酸剂的中和酸能力。结果:Rennie®咀嚼片的酸中和能力最强,AntacidAwa次之,Maalux®plus次之。酸中和能力最低的是Gaviscon®和Enoxon®混悬液。结论:酸中和能力是评价抗酸药疗效的一种简便、快捷的方法。不同的盐和浓度的组合会影响抗酸剂的中和酸能力。抗酸剂的中和效果越高,说明抗酸剂的效果越好。关键词:酸中和能力;抗酸剂;pH值;消化不良;埃尔比勒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Acid-neutralizing capacity of antacids in Erbil City
Background and objective: Antacids are basic substances that can neutralize hydrochloric acid and reduce gastric acidity. They are over the counter drugs used to treat dyspepsia. The most commonly used antacids are sodium bicarbonate, magnesium hydroxide, aluminum hydroxide, and calcium carbonate. This study aimed to evaluate the effectiveness of antacids that are commonly used in Erbil city by finding their acid-neutralizing capacity. Methods: The method for acid-neutralizing capacity was adapted from pharmacopeia. The samples were prepared by dissolving the antacid in an excess amount of hydrochloric acid, then neutralizing the excess acid with sodium hydroxide solution by doing back titration. The number of milliequivalents that are neutralized by the antacid is the acid-neutralizing capacity of the antacid. Results: Rennie® chewable tablet showed the highest acid-neutralizing capacity, followed by AntacidAwa and Maalux® plus. The lowest acid-neutralizing capacity was for the suspensions Gaviscon® and Enoxon®. Conclusion: Acid-neutralizing capacity is an easy and quick method to evaluate the efficacy of antacids. Different combinations of salts and concentrations can affect the acid-neutralizing capacity of the antacid. The higher the neutralizing effect of the antacid, the more effective the antacid is. Keywords: Acid-neutralizing capacity; Antacid; pH; Dyspepsia; Erbil.
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