从(n,p)反应生产锕-225:可行性和预设计研究

IF 0.7 4区物理与天体物理 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Nukleonika Pub Date : 2021-06-01 DOI:10.2478/nuka-2021-0008

F. Abolaban, E. Banoqitah, Eslam M. Taha, A. Alhawsawi, F. Djouider, A. Nisbet

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引用次数: 0

摘要

摘要锕-225在核医学中用于治疗恶性肿瘤。它可以用于在可重复使用的发生器中生产Bi-213，或者可以单独用作放射治疗，特别是靶向α治疗的试剂。然而，Ac-225在全球范围内的可用性，特别是在中低收入国家，是有限的。我们提出了一项可行性研究，采用开源蒙特卡罗模拟工具包GATE，从中子发生器生产Ac-225。这项工作表明，由三个同心圆柱体组成的设计，最内侧的是Cf-252中子源，中间的镍圆柱体用作质子产生靶，外侧的圆柱体是RaCl2靶，可以为Ac-225发生器提供可行的设计大纲。

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Production of actinium-225 from a (n,p) reaction: Feasibility and pre-design studies

Abstract Actinium-225 is used in nuclear medicine for the treatment of malignant tumours. It can be applied to produce Bi-213 in a reusable generator or can be used alone as an agent for radiation therapy, in particular for targeted alpha therapy. However, the availability of Ac-225 for worldwide use, particularly in low- and middle-income countries, is limited. We present a feasibility study employing GATE, an open-source Monte Carlo simulation toolkit, on the production of Ac-225 from a neutron generator. This work suggests that a design consisting of three concentric cylinders, the innermost a Cf-252 neutron source, the middle nickel cylinder acting as a proton-producing target and the outer cylinder a RaCl2 target may provide a feasible design outline for an Ac-225 generator.

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来源期刊

Nukleonika 物理-无机化学与核化学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： "Nukleonika" is an international peer-reviewed, scientific journal publishing original top quality papers on fundamental, experimental, applied and theoretical aspects of nuclear sciences. The fields of research include: radiochemistry, radiation measurements, application of radionuclides in various branches of science and technology, chemistry of f-block elements, radiation chemistry, radiation physics, activation analysis, nuclear medicine, radiobiology, radiation safety, nuclear industrial electronics, environmental protection, radioactive wastes, nuclear technologies in material and process engineering, radioisotope diagnostic methods of engineering objects, nuclear physics, nuclear reactors and nuclear power, reactor physics, nuclear safety, fuel cycle, reactor calculations, nuclear chemical engineering, nuclear fusion, plasma physics etc.