左氧氟沙星和诺氟沙星药物的光物理性质及其与咖啡因的荧光猝灭机理

IF 1.1 4区化学 Q3 SPECTROSCOPY

Spectroscopy Letters Pub Date : 2022-08-19 DOI:10.1080/00387010.2022.2110596

Kinfe Woldegiorges, A. Belay, A. Kebede

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引用次数: 1

摘要

摘要左氧氟沙星和诺氟沙星是用于治疗由细菌引起的各种感染的药物。在本研究中，使用紫外-可见吸收和荧光光谱技术研究了药物的光物理性质。结果表明，药物的荧光量子产率、寿命和非辐射衰变受溶剂极性和药物浓度的影响。采用荧光猝灭法测定了左氧氟沙星-咖啡因和诺氟沙星-咖啡因的结合机制。咖啡因引起的药物猝灭是由于基态复合物。由于静电作用，结合自发发生，氢和范德华力在反应中起主要作用。

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Photophysical properties of levofloxacin and norfloxacin drugs and their fluorescence quenching mechanism with caffeine

Abstract Levofloxacin and norfloxacin are drugs used to treat various infections originating from bacterial species. In this research, the photophysical properties of the drugs were investigated using ultraviolet–visible absorption and fluorescence spectroscopic techniques. The results indicated the fluorescence quantum yields, lifetime, and non-radiative decay of the drugs are affected by solvent polarity and drug concentration. The binding mechanism of levofloxacin–caffeine and norfloxacin–caffeine were determined using the fluorescence quenching method. The quenching of drugs induced by caffeine is due to ground state complexes. The binding occurs spontaneously due to electrostatics, hydrogen and Van der Waals force play a major role in the reaction.

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来源期刊

Spectroscopy Letters 物理-光谱学

CiteScore

2.90

自引率

5.90%

发文量

审稿时长

1.3 months

期刊介绍： Spectroscopy Letters provides vital coverage of all types of spectroscopy across all the disciplines where they are used—including novel work in fundamental spectroscopy, applications, diagnostics and instrumentation. The audience is intended to be all practicing spectroscopists across all scientific (and some engineering) disciplines, including: physics, chemistry, biology, instrumentation science, and pharmaceutical science.