高灵敏动力学分光光度法测定纯片和市售片中卡马西平的含量

Q3 Pharmacology, Toxicology and Pharmaceutics

Iraqi Journal of Pharmaceutical Sciences Pub Date : 2017-07-08 DOI:10.1234/ijps.v26i1.680

S. B. Dikran, F. Zankanah

{"title":"高灵敏动力学分光光度法测定纯片和市售片中卡马西平的含量","authors":"S. B. Dikran, F. Zankanah","doi":"10.1234/ijps.v26i1.680","DOIUrl":null,"url":null,"abstract":"The study aimed to recommend a new spectrophotometric-kinetic method for determination of carbamazepine (CABZ) in its pure form and pharmaceutical forms. The proposed procedure based on the coupling of CABZ with diazotized sulfanilic acid in basic medium to yield a colored azo dye. Factors affecting the reaction yield were studied and the conditions were optimized. The colored product was followed spectrophotometrically via monitoring its absorbance at 396 nm. Under the optimized conditions, two method (the initial rate and fixed time (10 minute)) were applied for constructing the calibration graphs. The graphs were linear in concentration ranges 2.0 to 18.0 Âµg.mL-1 for both methods. The proposed was applied successfully in the determination of CABZ in its commercial formulations. \nKeywords: Kinetic, Spectrophotometry, Carbamazepine, Pharmaceutical formulations","PeriodicalId":14600,"journal":{"name":"Iraqi Journal of Pharmaceutical Sciences","volume":"26 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2017-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Highly Sensitive Kinetic-Spectrophotometric Method for the Assay of Carbamazepine in Pure and Commercial Tablet\",\"authors\":\"S. B. Dikran, F. Zankanah\",\"doi\":\"10.1234/ijps.v26i1.680\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The study aimed to recommend a new spectrophotometric-kinetic method for determination of carbamazepine (CABZ) in its pure form and pharmaceutical forms. The proposed procedure based on the coupling of CABZ with diazotized sulfanilic acid in basic medium to yield a colored azo dye. Factors affecting the reaction yield were studied and the conditions were optimized. The colored product was followed spectrophotometrically via monitoring its absorbance at 396 nm. Under the optimized conditions, two method (the initial rate and fixed time (10 minute)) were applied for constructing the calibration graphs. The graphs were linear in concentration ranges 2.0 to 18.0 Âµg.mL-1 for both methods. The proposed was applied successfully in the determination of CABZ in its commercial formulations. \\nKeywords: Kinetic, Spectrophotometry, Carbamazepine, Pharmaceutical formulations\",\"PeriodicalId\":14600,\"journal\":{\"name\":\"Iraqi Journal of Pharmaceutical Sciences\",\"volume\":\"26 1\",\"pages\":\"1-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iraqi Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1234/ijps.v26i1.680\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iraqi Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1234/ijps.v26i1.680","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

摘要

本研究旨在推荐一种新的动力学分光光度法测定卡马西平（CABZ）的纯形式和药物形式。提出了一种基于CABZ与重氮化氨基苯胺酸在碱性介质中偶联产生有色偶氮染料的方法。研究了影响反应收率的因素，并对反应条件进行了优化。通过监测其在396nm处的吸光度，用分光光度法跟踪着色产物。在优化条件下，采用两种方法（初始速率和固定时间（10分钟））构建校准图。两种方法的曲线图在2.0至18.0µg.mL-1的浓度范围内呈线性。该方法已成功应用于商业制剂中CABZ的测定。关键词：动力学，分光光度法，卡马西平，药物制剂

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A Highly Sensitive Kinetic-Spectrophotometric Method for the Assay of Carbamazepine in Pure and Commercial Tablet

The study aimed to recommend a new spectrophotometric-kinetic method for determination of carbamazepine (CABZ) in its pure form and pharmaceutical forms. The proposed procedure based on the coupling of CABZ with diazotized sulfanilic acid in basic medium to yield a colored azo dye. Factors affecting the reaction yield were studied and the conditions were optimized. The colored product was followed spectrophotometrically via monitoring its absorbance at 396 nm. Under the optimized conditions, two method (the initial rate and fixed time (10 minute)) were applied for constructing the calibration graphs. The graphs were linear in concentration ranges 2.0 to 18.0 Âµg.mL-1 for both methods. The proposed was applied successfully in the determination of CABZ in its commercial formulations. Keywords: Kinetic, Spectrophotometry, Carbamazepine, Pharmaceutical formulations

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Iraqi Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

24 weeks