皮下免疫球蛋白治疗原发性肠淋巴管扩张患者的成功免疫球蛋白替代疗法

IF 0.3 Q4 ALLERGY
G. Aytekin, Fatih Çölkesen, Ö. Ardeniz, Z. Caliskaner
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引用次数: 1

摘要

原发性肠淋巴管扩张症是一种罕见的疾病,其特征是小肠淋巴引流受损。位于粘膜、粘膜下层或浆膜下的扩张淋巴通道的蛋白质损失,导致γ球蛋白和淋巴细胞的损失,导致体液和细胞免疫受损。在此,我们报告了一位61岁的原发性肠淋巴管扩张症(PIL)继发免疫缺陷患者,我们只能通过皮下IgG替代而不是静脉注射IgG来获得有效和稳定的IgG水平。我们的经验表明,皮下免疫球蛋白(SCIG)替代导致更稳定的IgG水平在呈示的PIL患者。我们的结论是,SCIG应该是免疫球蛋白替代治疗的首选途径,在继发性低γ -球蛋白血症,由于蛋白质丢失肠病,特别是在PIL。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Successful Immunoglobulin Replacement with Subcutaneous Immunoglobulin Therapy in a Patient with Primary Intestinal Lymphangiectasia
Primary intestinal lymphangiectasia is a rare disorder which characterized by impaired small intestinal lymph drainage. There is loss of proteins from dilated lymphatic channels located in the mucosa, submucosa or subserosa which is results with loss of gammaglobulins and lymphocytes, leading to impaired humoral and cellular immunity. Herein, we present a 61-year-old patient with immunodeficiency secondary to Primary intestinal lymphangiectasia (PIL), in whom we could attain effective and stable IgG levels only by subcutaneous IgG replacement rather than intravenous IgG. Our experience suggests that Subcutaneous Immunoglobulin (SCIG) replacement resulted in more stable levels of IgG in the presented patient with PIL. We concluded that SCIG should be the preferred route of immunoglobulin replacement therapy in secondary hypogammaglobulinemia due to protein losing enteropathy, especially in PIL.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
10
期刊介绍: Asthma Allergy Immunology has been published three times a year in April, August and December as the official and periodical journal of the Turkish National Society of Allergy and Clinical Immunology since 2003. All articles published in the journal have been available online since 2003. A peer reviewed system is used in evaluation of the manuscripts submitted to Asthma Allergy Immunology. The official language of the journal is English. The aim of the journal is to present advances in the field of allergic diseases and clinical immunology to the readers. In accordance with this goal, manuscripts in the format of original research, review, case report, articles about clinical and practical applications and editorials, short report and letters to the editor about allergic diseases and clinical immunology are published in the journal. The target reader population of the Asthma Allergy Immunology includes specialists and residents of allergy and clinical immunology, pulmonology, internal medicine, pediatrics, dermatology and otolaryngology as well as physicians working in other fields of medicine interested in allergy and immunological diseases.
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