胃组织活检的穆勒显微镜光学诊断及统计分析

IF 1.9 4区物理与天体物理 Q3 OPTICS

Journal of the European Optical Society-Rapid Publications Pub Date : 2022-10-24 DOI:10.1051/jeos/2022011

T. Novikova, Myeongseop Kim, Hee Ryung Lee, R. Ossikovski, Aude Malfait-Jobart, D. Lamarque

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引用次数: 10

摘要

我们研究了通过使用胃活检的Mueller显微镜、回归模型和预测图像的统计分析，产生定量光学指标以表征胃组织从健康状态通过炎症到癌症的演变的可能性。为此，使用定制的Mueller显微镜测量了不同病理条件下人类胃组织活检的未染色切片。利用透射强度、延迟、二向色性和去偏振图建立多项式回归模型，生成预测图像。对胃组织切片预测图像的多曲线拟合统计分析表明，Mueller显微镜结合数据回归和统计分析是定量评估胃组织活检炎症程度的有效方法，在临床应用中具有很高的潜力。

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Optical diagnosis of gastric tissue biopsies with Mueller microscopy and statistical analysis

We investigate a possibility of producing the quantitative optical metrics to characterize the evolution of gastric tissue from healthy conditions via inflammation to cancer by using Mueller microscopy of gastric biopsies, regression model and statistical analysis of the predicted images. For this purpose the unstained sections of human gastric tissue biopsies at different pathological conditions were measured with the custom-built Mueller microscope. Polynomial regression model was built using the maps of transmitted intensity, retardance, dichroism and depolarization to generate the predicted images. The statistical analysis of predicted images of gastric tissue sections with multi-curve fit suggests that Mueller microscopy combined with data regression and statistical analysis is an effective approach for quantitative assessment of the degree of inflammation in gastric tissue biopsies with a high potential in clinical applications.

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来源期刊

Journal of the European Optical Society-Rapid Publications 物理-光学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： Rapid progress in optics and photonics has broadened its application enormously into many branches, including information and communication technology, security, sensing, bio- and medical sciences, healthcare and chemistry. Recent achievements in other sciences have allowed continual discovery of new natural mysteries and formulation of challenging goals for optics that require further development of modern concepts and running fundamental research. The Journal of the European Optical Society – Rapid Publications (JEOS:RP) aims to tackle all of the aforementioned points in the form of prompt, scientific, high-quality communications that report on the latest findings. It presents emerging technologies and outlining strategic goals in optics and photonics. The journal covers both fundamental and applied topics, including but not limited to: Classical and quantum optics Light/matter interaction Optical communication Micro- and nanooptics Nonlinear optical phenomena Optical materials Optical metrology Optical spectroscopy Colour research Nano and metamaterials Modern photonics technology Optical engineering, design and instrumentation Optical applications in bio-physics and medicine Interdisciplinary fields using photonics, such as in energy, climate change and cultural heritage The journal aims to provide readers with recent and important achievements in optics/photonics and, as its name suggests, it strives for the shortest possible publication time.