新兴的个性化虚拟脑模型:耐药癫痫的新一代切除神经外科?

IF 1.2 Q4 CLINICAL NEUROLOGY
Qiao Wang, Guangyuan Jin, Tao Yu, Fabrice Bartolomei, Liankun Ren
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引用次数: 0

摘要

最近,艾克斯马赛大学的一个研究小组在《柳叶刀神经病学》、《科学转化医学》和《癫痫病》上发表的论文中提出了一种名为虚拟癫痫患者(VEP)的新工作流程。该方法基于计算建模建立个性化的虚拟脑模型,通过估计癫痫区和实施虚拟手术来促进临床决策。在此,我们总结了VEP的工作流程、优势和局限性,以及它在53例接受立体脑电图检查的耐药局灶性癫痫患者中的表现。一项大规模临床试验(NCT03643016)正在进行中,以进一步评估VEP,预计将招募356名患者。随着支持证据的积累,VEP的临床应用有可能改善临床实践,导致更好的结果和患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Emerging personalized virtual brain models: next-generation resection neurosurgery for drug-resistant epilepsy?

Emerging personalized virtual brain models: next-generation resection neurosurgery for drug-resistant epilepsy?

Recently, a novel workflow known as the virtual epileptic patient (VEP) has been proposed by a research team from Aix Marseille Université in their papers published in Lancet Neurology, Science Translational Medicine and Epilepsia. This method involves creating an individualized virtual brain model based on computational modelling, which can facilitate clinical decision-making by estimating the epileptogenic zone and performing the virtual surgery. Here, we summarize brief workflow, strengths, and limitations of VEP, as well as its performance in a retrospective study of 53 patients with drug-resistant focal epilepsy who underwent stereoelectroencephalography. A large-scale clinical trial (NCT03643016) is underway to further assess VEP, which is expected to enroll 356 patients prospectively. As supporting evidence accumulates, the clinical application of VEP has the potential to improve clinical practice, leading to better outcomes and qualities of life of patients.

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来源期刊
Acta Epileptologica
Acta Epileptologica Medicine-Neurology (clinical)
CiteScore
2.00
自引率
0.00%
发文量
38
审稿时长
20 weeks
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