血清同型半胱氨酸、叶酸及卵黄囊超声检测对先兆流产预后的预测价值

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2019-03-01 DOI:10.1515/pteridines-2019-0002

Wenhai Wu, Qi Ji, Baoliang Guo, Jinfen Yu, Jiewei Wang, Yezhu Wang, Juan-Ying Xu

{"title":"血清同型半胱氨酸、叶酸及卵黄囊超声检测对先兆流产预后的预测价值","authors":"Wenhai Wu, Qi Ji, Baoliang Guo, Jinfen Yu, Jiewei Wang, Yezhu Wang, Juan-Ying Xu","doi":"10.1515/pteridines-2019-0002","DOIUrl":null,"url":null,"abstract":"Abstract Background: To investigate the clinical value of serum homocysteine (Hcy), folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion.Methods: Ninety-eight pregnant women within 12 weeks of gestation were included in the study. Of these subjects, 29 presented with threatened abortion and were considered the case group (n=29). The other 69 subjects showed as a normal pregnancy were the control group (n=69). The case group was followed up with at 28 weeks of gestation, and further divided into inevitable abortion group (IA, n=9) and successful fetus protection group (SFP, n=20). The yolk sacs of the included cases were measured by ultrasonography. The serum Hcy and folate levels of the included cases were measured by an enzyme cycling assay and chemiluminescent immunoassay, respectively. The yolk sac visualization rate and serum Hcy and folate levels were compared between the two case groups and used as a predicting reference for the outcome of threatened abortion. Results: The yolk sac visualization rates detected by ultrasonography were 97.1% (67/69) for the control group and 69.0% (20/29) for the threatened abortion group, with a statistical difference (p<0.05). For the IA and SFP groups, the visualization rates were 22.2% (2/9) and 90.0% (18/20) respectively, with a statistical difference (p<0.05). The serum Hcy levels in the threatened abortion group were significant elevated compared with control group (6.1±2.0 μmol/L vs 4.5±1.3 μmol/L), with a statistical difference (p<0.05). However, the serum levels of folat in the threatened abortion group were significantly decreased compared with the control group (15.5±4.2 nmol/L vs 19.1±4.7 nmol/L), with a statistical difference (p<0.05). The serum levels of Hcy and folate were 7.5±1.7 μmol/L and 12.7±4.2 nmol/L for the IA group, which were statistically different compared to the SFP group (p<0.05). The predictive sensitivity for the outcome of threatened abortion based on serum Hcy and folate levels were 85.0% and 75.0%, with a predictive specificity of 66.7% and 88.9% respectively. Conclusion: Serum Hcy and folate levels were quite different in threatened abortion pregnant woman compared to the control group. Serum Hcy and folate level detection combined with ultrasonography detection of yolk sac can provide useful information for threatened abortions","PeriodicalId":20792,"journal":{"name":"Pteridines","volume":"30 1","pages":"10 - 15"},"PeriodicalIF":0.5000,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/pteridines-2019-0002","citationCount":"1","resultStr":"{\"title\":\"Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion\",\"authors\":\"Wenhai Wu, Qi Ji, Baoliang Guo, Jinfen Yu, Jiewei Wang, Yezhu Wang, Juan-Ying Xu\",\"doi\":\"10.1515/pteridines-2019-0002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Background: To investigate the clinical value of serum homocysteine (Hcy), folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion.Methods: Ninety-eight pregnant women within 12 weeks of gestation were included in the study. Of these subjects, 29 presented with threatened abortion and were considered the case group (n=29). The other 69 subjects showed as a normal pregnancy were the control group (n=69). The case group was followed up with at 28 weeks of gestation, and further divided into inevitable abortion group (IA, n=9) and successful fetus protection group (SFP, n=20). The yolk sacs of the included cases were measured by ultrasonography. The serum Hcy and folate levels of the included cases were measured by an enzyme cycling assay and chemiluminescent immunoassay, respectively. The yolk sac visualization rate and serum Hcy and folate levels were compared between the two case groups and used as a predicting reference for the outcome of threatened abortion. Results: The yolk sac visualization rates detected by ultrasonography were 97.1% (67/69) for the control group and 69.0% (20/29) for the threatened abortion group, with a statistical difference (p<0.05). For the IA and SFP groups, the visualization rates were 22.2% (2/9) and 90.0% (18/20) respectively, with a statistical difference (p<0.05). The serum Hcy levels in the threatened abortion group were significant elevated compared with control group (6.1±2.0 μmol/L vs 4.5±1.3 μmol/L), with a statistical difference (p<0.05). However, the serum levels of folat in the threatened abortion group were significantly decreased compared with the control group (15.5±4.2 nmol/L vs 19.1±4.7 nmol/L), with a statistical difference (p<0.05). The serum levels of Hcy and folate were 7.5±1.7 μmol/L and 12.7±4.2 nmol/L for the IA group, which were statistically different compared to the SFP group (p<0.05). The predictive sensitivity for the outcome of threatened abortion based on serum Hcy and folate levels were 85.0% and 75.0%, with a predictive specificity of 66.7% and 88.9% respectively. Conclusion: Serum Hcy and folate levels were quite different in threatened abortion pregnant woman compared to the control group. Serum Hcy and folate level detection combined with ultrasonography detection of yolk sac can provide useful information for threatened abortions\",\"PeriodicalId\":20792,\"journal\":{\"name\":\"Pteridines\",\"volume\":\"30 1\",\"pages\":\"10 - 15\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2019-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1515/pteridines-2019-0002\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pteridines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1515/pteridines-2019-0002\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pteridines","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/pteridines-2019-0002","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 1

摘要

摘要背景:探讨血清同型半胱氨酸(Hcy)、叶酸及卵黄囊超声检测对先兆流产结局的预测价值。方法:98例妊娠12周以内的孕妇纳入研究。在这些受试者中，29例出现先兆流产，被认为是病例组(n=29)。其余69例正常妊娠者为对照组(n=69)。病例组于妊娠28周进行随访，并进一步分为不可流产组(IA, n=9)和保胎成功组(SFP, n=20)。超声检查各组卵黄囊。采用酶循环法和化学发光免疫法分别测定血清Hcy和叶酸水平。比较两组患者卵黄囊显影率、血清Hcy和叶酸水平，并以此作为先兆流产结局的预测参考。结果:对照组和先兆流产组卵黄囊显像率分别为97.1%(67/69)和69.0%(20/29)，差异有统计学意义(p<0.05)。IA组和SFP组的显像率分别为22.2%(2/9)和90.0%(18/20)，差异有统计学意义(p<0.05)。先兆流产组血清Hcy水平显著高于对照组(6.1±2.0 μmol/L vs 4.5±1.3 μmol/L)，差异有统计学意义(p<0.05)。先兆流产组血清叶酸水平明显低于对照组(15.5±4.2 nmol/L vs 19.1±4.7 nmol/L)，差异有统计学意义(p<0.05)。IA组血清Hcy和叶酸水平分别为7.5±1.7 μmol/L和12.7±4.2 nmol/L，与SFP组比较差异有统计学意义(p<0.05)。血清Hcy和叶酸水平对先兆流产结局的预测敏感性分别为85.0%和75.0%，预测特异性分别为66.7%和88.9%。结论:先兆流产孕妇血清Hcy和叶酸水平与对照组有较大差异。血清Hcy和叶酸水平检测结合卵黄囊超声检查可为先兆流产提供有用信息

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Clinical value of serum homocysteine, folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion

Abstract Background: To investigate the clinical value of serum homocysteine (Hcy), folate, and ultrasonography detection of yolk sac in predicting the outcome of threatened abortion.Methods: Ninety-eight pregnant women within 12 weeks of gestation were included in the study. Of these subjects, 29 presented with threatened abortion and were considered the case group (n=29). The other 69 subjects showed as a normal pregnancy were the control group (n=69). The case group was followed up with at 28 weeks of gestation, and further divided into inevitable abortion group (IA, n=9) and successful fetus protection group (SFP, n=20). The yolk sacs of the included cases were measured by ultrasonography. The serum Hcy and folate levels of the included cases were measured by an enzyme cycling assay and chemiluminescent immunoassay, respectively. The yolk sac visualization rate and serum Hcy and folate levels were compared between the two case groups and used as a predicting reference for the outcome of threatened abortion. Results: The yolk sac visualization rates detected by ultrasonography were 97.1% (67/69) for the control group and 69.0% (20/29) for the threatened abortion group, with a statistical difference (p<0.05). For the IA and SFP groups, the visualization rates were 22.2% (2/9) and 90.0% (18/20) respectively, with a statistical difference (p<0.05). The serum Hcy levels in the threatened abortion group were significant elevated compared with control group (6.1±2.0 μmol/L vs 4.5±1.3 μmol/L), with a statistical difference (p<0.05). However, the serum levels of folat in the threatened abortion group were significantly decreased compared with the control group (15.5±4.2 nmol/L vs 19.1±4.7 nmol/L), with a statistical difference (p<0.05). The serum levels of Hcy and folate were 7.5±1.7 μmol/L and 12.7±4.2 nmol/L for the IA group, which were statistically different compared to the SFP group (p<0.05). The predictive sensitivity for the outcome of threatened abortion based on serum Hcy and folate levels were 85.0% and 75.0%, with a predictive specificity of 66.7% and 88.9% respectively. Conclusion: Serum Hcy and folate levels were quite different in threatened abortion pregnant woman compared to the control group. Serum Hcy and folate level detection combined with ultrasonography detection of yolk sac can provide useful information for threatened abortions

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.