ICD-85在体内和体外治疗肿瘤中的作用

Asia Pacific Journal of Medical Toxicology Pub Date : 2019-12-01 DOI:10.22038/APJMT.2019.14807

Mohammad Reza Zinatizadeh, A. Z. Mirakabadi, Peyman Kheirandish Zarandi, H. Mirzaei, Farzaneh Parnak, Sholeh D. Javadi

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引用次数: 2

摘要

背景：癌症是目前全球女性中最重要的癌症类型，占癌症所有类型的25%。癌症的预防和治疗至关重要。方法：治疗癌症的主要方法包括化疗、手术、放疗、基因治疗和激素治疗。化学预防试验计划始于1987年，当时在针对各种类型癌症的化学预防活性的临床前研究中选择并评估了1000多种药物和药物组合。结果：抗癌药物的一个重要特征是对癌症细胞的细胞毒性作用；这些药物在动物毒液中发现了一些细胞毒性物质。ICD-85是三种肽的组合，范围从10000到30000Da，来源于伊朗褐蛇（Gloydius halys）和黄蝎（Hemisscorpius lepturus）的毒液。结论：ICD-85对癌症细胞具有抗增殖和抗血管生成活性。化疗的副作用包括多重耐药性和对自然组织的影响等。因此，细胞毒性抗癌药物可用于治疗癌症。本工作研究ICD-85对体内外研究的影响。

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The Effects of ICD-85 in vivo and in vitro in Treatment of Cancer

Background: Breast cancer is now the most important type of cancer in women around the globe and accounts for 25% of all types of cancer. Prevention and treatment of cancer are essential. Method: The main methods for treating cancer include chemotherapy, surgery, radiotherapy, gene therapy, and hormone therapy. Chemopreventive test programmes began in 1987, when over 1,000 agents and agent combinations were selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers. Results: An important feature of anticancer drugs is a cytotoxic effect on cancer cells; these drugs have some cytotoxic agents found in animal venom. The ICD-85 is a combination of three peptides, ranging from 10,000 to 30,000 Da, and derived from the venom of the Iranian brown snake (Gloydius halys) and the yellow scorpion (Hemiscorpius lepturus). Conclusion: ICD-85 has an anti-proliferative effect and anti-angiogenesis activity on cancer cells. The side effects of chemotherapy are multiple drug resistance and effects on natural tissues, among others. Therefore, cytotoxic anticancer drugs are useful in treating cancer. The present work investigates the effects of ICD-85 on in vivo and in vitro studies.

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来源期刊

Asia Pacific Journal of Medical Toxicology

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Asia Pacific Journal of Medical Toxicology (APJMT) aims to expand the knowledge of medical toxicology and tries to provide reliable information in this field for medical and healthcare professionals. APJMT mainly focuses on research related to medical toxicology issues in the Asia Pacific region and publishes articles on clinical and epidemiological aspects of toxicology, poisonings emergency care, addiction, drug interactions and adverse effects. The journal accepts and welcomes high quality papers in the form of original articles and rarely review articles, case reports and scientific letters relevant to medical practice in toxicology.