双相现成霰石种植体修复早期OA关节软骨

IF 0.4 4区 医学 Q4 SPORT SCIENCES
Enrico Maria Bertolino , Berardo Di Matteo , Daniele Altomare , Elizaveta Kon
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引用次数: 1

摘要

骨关节炎(OA)是指一组机械诱导的以表观遗传为特征的关节疾病。它被定义为整个关节的疾病。关节软骨细胞和软骨下骨细胞不断受到应力、应变和负荷的影响,如果体内平衡和修复过程无法补偿这些破坏过程,关节环境就会受到损害,并出现结构损伤和临床症状。由于缺乏能够治愈OA患者的药物,导致使用关节内浸润和外科手术,其中植入仿生支架。仿生支架是一种创新材料,旨在促进骨骼和软骨再生。最新一代支架的发展目标是提高人体自身细胞和信号因子的愈合能力,以达到更高的组织质量和更好的临床效果。本文报道双相文石支架在早期OA患者膝关节上的体内性能。生物支架的植入已通过mri,随访时的kos评分和组织学进行评估。Agili-C支架的分析表明,它是轻度至中度OA患者的可行选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Biphasic Aragonite off the Shelf Implant for Articular Cartilage Restoration in Early OA

Osteoarthritis (OA) refers to a group of mechanically induced joint disorders characterized by an epigenetic nature. It has been defined as a disease of the entire joint. Articular chondrocytes and subchondral osteocytes are constantly subject to stress, strain and load and, if homeostatic and reparative processes are unable to compensate for the destructive processes, the joint environment will suffer and present with structural damage and clinical symptoms. The lack of drugs able to cure patients from OA has resulted in the use of intra-articular infiltrations and surgical procedures among which the implantation of biomimetic scaffolds. Biomimetic scaffolds are innovative materials created with the aim of encouraging bone and cartilage regeneration. The latest generation of scaffolds has been developed with the aim of increasing the healing abilities of the human body's own cells and signaling factors to achieve a superior tissue quality and better clinical outcomes. The present paper presents the in vivo performance of biphasic aragonite scaffolds on knees affected by early OA. The implantation of bioscaffolds has been been evaluated with MRIs, KOOS scores at follow up and histologically. The Agili-C scaffold's analysis has revealed it to be a viable option in the use of patients with mild to moderate OA.

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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
46
审稿时长
93 days
期刊介绍: Operative Techniques in Sports Medicine combines the authority of a textbook, the usefulness of a color atlas and the timeliness of a journal. Each issue focuses on a single clinical condition, offering several different management approaches. It''s the easiest way for practitioners to stay informed of the latest surgical advancements and developments.
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