LINAC立体定向放射外科技术治疗更多脑动静脉畸形

Ricardo Reyes
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引用次数: 0

摘要

所有13例患者均在三年内接受了基于线性加速器的治疗传递系统(BrainLab)的立体定向放射手术。其中男性7名,女性6名,中位年龄22岁。颅内出血是7例(54%)患者的主要表现。在10例(77%)患者中,有7例患者接受过一次以上的栓塞治疗。AVM的位置为浅表9例(70%),脑深部4例(30%)。AVM平均评分为0.97,其中3例AVM评分≥1,平均Spetzler-Martin分级为2.7,8例(62%)AVM评分为3级及以上。中位随访时间为30个月。单次平均剂量为21.7 Gy。AVM病灶完全闭塞9例(70%),部分闭塞4例(30%)。在AVM评分小于1分的9例患者中,有6例(67%)实现了完全消除。放疗后仅1例患者出现右侧颞野丧失的神经功能缺损。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LINAC treating more patients having brain arteriovenous malformations with stereotactic radiosurgery technique
All thirteen patients underwent stereotactic radiosurgery by linear accelerator based treatment delivery system (BrainLab) over three years. These included 7 males and 6 females, with median age of 22 years. Intracranial hemorrhage was a presenting feature in 7 (54 %) of patients. Prior embolization was done in 10 (77%) patients with 7 patients having more than once undergone this procedure. The location of AVM was superficial in 9 (70%) and deep in brain in 4 (30%) patients. The mean AVM score was 0.97 with 3 patients having AVM score ≥ 1 with mean Spetzler-Martin grade of 2.7 and 8 (62%) patients having grade 3 or more. Median follow up was 30 months. Mean dose delivered was 21.7 Gy in single fraction. Complete obliteration of AVM nidus was achieved in 9 (70%) patients while 4 patients (30%) had partial obliteration. Six patients (67 %) achieved complete obliteration among 9 who had AVM score of less than 1. Post radiosurgery neurological deficit occurred in only one patient in form of right temporal field loss.
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