利用纳米沉淀法从生物相容性己二酸基共聚物中获得负载维生素e的聚合物纳米颗粒

IF 1.1 4区工程技术 Q4 POLYMER SCIENCE

Polimery Pub Date : 2022-11-30 DOI:10.14314/polimery.2022.11.1

Martyna Sokołowska, Maja Marchwiana, M. El Fray

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引用次数: 1

摘要

以天然来源的单体为原料，酶促合成了新型脂肪族生物聚酯——聚己二酸丁烯-邻己二醇(PBA-DLA)。利用南极念珠菌(CALB)脂肪酶B作为生物催化剂。PBA-DLA共聚酯的化学结构经1H NMR确证。体外生物学研究未发现其对小鼠成纤维细胞有细胞毒作用。采用单级纳米沉淀法获得的PBA-DLA纳米颗粒包封维生素E的主要成分疏水性α-生育酚(α-TP)，包封效率为48−74% (EE%)，不同浓度α-TP (2.5;5;10 mg/ml)，通过动态光散射(DLS)分析、紫外光谱(UV-VIS)和1H NMR证实。

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Vitamin E-loaded polymeric nanoparticles from biocompatible adipate-based copolymer obtained using the nanoprecipitation method

An enzymatic synthesis of new aliphatic biopolyesters - poly(butylene adipate)-co-(dilinol adipate) (PBA-DLA) with the use of monomers obtained from natural sources was carried out. Lipase B from the strain Candida antarctica (CALB) was used as a biocatalyst. The chemical structure of the PBA-DLA copolyester was confirmed by 1H NMR. In vitro biological studies did not show its cytotoxic effect on mouse fibroblast cells. PBA-DLA nanoparticles obtained in a single-stage nanoprecipitation process were used to encapsulate hydrophobic α-tocopherol (α-TP), the main component of vitamin E, obtaining an encapsulation efficiency of 48−74% (EE%) depending on the concentration of α-TP (2.5 ; 5; 10 mg/ml), which was confirmed by dynamic light scattering (DLS) analysis, ultraviolet spectroscopy (UV-VIS) and 1H NMR.

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来源期刊

Polimery Materials Science-Polymers and Plastics

CiteScore

2.90

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： The "Polimery" journal, of international circulation, is publishing peerreviewed scientific and technical research papers covering polymer science and technology in the field of polymers, rubbers, chemical fibres and paints. The range of topics covered are raw materials, polymer synthesis, processing and applications of polymers. Apart from scientific and technical research papers the monthly includes technical and commercial information such as reports from fairs and exhibitions as well as home, world and technical news. “Polimery "- an international journal covering the following topics: polymers, rubber, chemical fibres and paints. The Journal is addressed to scientists, managers and engineering staff of universities, Polish Academy of Sciences, R&D institutions, industry, specializing in polymer chemistry, physical chemistry, technology and processing. “Polimery” publishes original, reviewed research, scientific and technology papers in the field of polymer synthesis, analysis, technology and modification, processing, properties, applications and recycling.