小儿弥漫性脑桥内胶质瘤的不典型临床表现及预后分析

Q4 Medicine

中华神经外科杂志 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1001-2346.2019.11.011

Peng Zhang, Changcun Pan, Yuliang Wu, Xiong Xiao, Lu Kong, Zhen Wu, Junting Zhang, Liwei Zhang

{"title":"小儿弥漫性脑桥内胶质瘤的不典型临床表现及预后分析","authors":"Peng Zhang, Changcun Pan, Yuliang Wu, Xiong Xiao, Lu Kong, Zhen Wu, Junting Zhang, Liwei Zhang","doi":"10.3760/CMA.J.ISSN.1001-2346.2019.11.011","DOIUrl":null,"url":null,"abstract":"Objective \nTo analyze the atypical clinical manifestations and clinical prognosis of pediatric diffuse intrinsic pontine glioma (DIPG). \n \n \nMethods \nA total of 27 patients with complete clinical data of DIPG undergoing clinical treatment at Neurosurgery Department of Beijing Tiantan Hospital, Capital Medical University from November 2015 to November 2017 were retrospectively enrolled into this study. All patients were divided into 2 groups according to the presence of atypical manifestations: atypical clinical manifestation group (17 cases) and the control group (10 cases). Among the 27 cases, 16 patients underwent stereotactic biopsy or open cranial biopsy, and the other 11 patients underwent tumor excision through craniotomy. All the children were followed up clinically or by telephone after operation to study the clinical outcomes. Comparative analysis was conducted on those clinical data. Prognosis was compared between the 2 groups through Kaplan-Meier survival analysis. \n \n \nResults \nAmong the 27 cases, 20 were pathologically identified as high grade gliomas (including 4 cases of diffuse midline glioma, 6 cases of glioblastoma, 6 cases of anaplastic oligoastrocytoma, 4 cases of anaplastic astrocytoma) and 7 as low grade glioma (including 4 cases of oligoastrocytoma and 3 cases of astrocytoma). One child suffered from pneumonia and finally recovered postoperatively. No statistically significant difference (all P>0.05) was identified between 2 groups in the age, gender, clinical manifestation (including cranial nerve palsy, long tract dysfunction and cerebellum signs), clinical imaging features (including lesion enhancement, supratentorial ventricle enlargement and brachium pontis involvement), clinical treatment or pathology. Kaplan-Meier survival analysis showed that patients with atypical clinical manifestation had significantly higher cumulative survival rate than those in the control group (P=0.045). \n \n \nConclusion \nAtypical clinical manifestation could be identified in some pediatric DIPG patients, which might be predictive of a better prognosis. \n \n \nKey words: \nBrainstem tumor; Child; Atypical clinical manifestation","PeriodicalId":10100,"journal":{"name":"中华神经外科杂志","volume":"35 1","pages":"1124-1128"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Atypical clinical manifestations and prognosis analysis of pediatric diffuse intrinsic pontine glioma\",\"authors\":\"Peng Zhang, Changcun Pan, Yuliang Wu, Xiong Xiao, Lu Kong, Zhen Wu, Junting Zhang, Liwei Zhang\",\"doi\":\"10.3760/CMA.J.ISSN.1001-2346.2019.11.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo analyze the atypical clinical manifestations and clinical prognosis of pediatric diffuse intrinsic pontine glioma (DIPG). \\n \\n \\nMethods \\nA total of 27 patients with complete clinical data of DIPG undergoing clinical treatment at Neurosurgery Department of Beijing Tiantan Hospital, Capital Medical University from November 2015 to November 2017 were retrospectively enrolled into this study. All patients were divided into 2 groups according to the presence of atypical manifestations: atypical clinical manifestation group (17 cases) and the control group (10 cases). Among the 27 cases, 16 patients underwent stereotactic biopsy or open cranial biopsy, and the other 11 patients underwent tumor excision through craniotomy. All the children were followed up clinically or by telephone after operation to study the clinical outcomes. Comparative analysis was conducted on those clinical data. Prognosis was compared between the 2 groups through Kaplan-Meier survival analysis. \\n \\n \\nResults \\nAmong the 27 cases, 20 were pathologically identified as high grade gliomas (including 4 cases of diffuse midline glioma, 6 cases of glioblastoma, 6 cases of anaplastic oligoastrocytoma, 4 cases of anaplastic astrocytoma) and 7 as low grade glioma (including 4 cases of oligoastrocytoma and 3 cases of astrocytoma). One child suffered from pneumonia and finally recovered postoperatively. No statistically significant difference (all P>0.05) was identified between 2 groups in the age, gender, clinical manifestation (including cranial nerve palsy, long tract dysfunction and cerebellum signs), clinical imaging features (including lesion enhancement, supratentorial ventricle enlargement and brachium pontis involvement), clinical treatment or pathology. Kaplan-Meier survival analysis showed that patients with atypical clinical manifestation had significantly higher cumulative survival rate than those in the control group (P=0.045). \\n \\n \\nConclusion \\nAtypical clinical manifestation could be identified in some pediatric DIPG patients, which might be predictive of a better prognosis. \\n \\n \\nKey words: \\nBrainstem tumor; Child; Atypical clinical manifestation\",\"PeriodicalId\":10100,\"journal\":{\"name\":\"中华神经外科杂志\",\"volume\":\"35 1\",\"pages\":\"1124-1128\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华神经外科杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1001-2346.2019.11.011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华神经外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1001-2346.2019.11.011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

目的分析儿童弥漫性桥脑胶质瘤的非典型临床表现及临床预后。方法回顾性分析2015年11月至2017年11月在首都医科大学北京天坛医院神经外科接受临床治疗的27例DIPG患者的临床资料。根据非典型临床表现将所有患者分为2组：非典型临床表现组（17例）和对照组（10例）。在27例病例中，16例患者接受了立体定向活检或开放性颅骨活检，另外11例患者通过开颅术进行了肿瘤切除。所有患儿术后均进行了临床随访或电话随访，以研究临床结果。对这些临床数据进行了比较分析。通过Kaplan-Meier生存分析比较两组患者的预后。结果27例患者中，病理诊断为高级别胶质瘤20例（其中弥漫性中线胶质瘤4例，胶质母细胞瘤6例，间变性少星形细胞瘤6例行，间变性星形细胞瘤4例行），低级别胶质瘤7例（其中少星形细胞癌4例行，星形细胞瘤3例行）。一名儿童患有肺炎，最终在术后康复。两组在年龄、性别、临床表现（包括脑神经麻痹、长束功能障碍和小脑体征）、临床影像学特征（包括病变增强、幕上脑室增大和桥臂受累）、临床治疗或病理学方面均无统计学意义（均P>0.05）。Kaplan-Meier生存分析显示，临床表现不典型的患者的累计生存率明显高于对照组（P=0.045）。关键词：脑干肿瘤；儿童；非典型临床表现

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Atypical clinical manifestations and prognosis analysis of pediatric diffuse intrinsic pontine glioma

Objective To analyze the atypical clinical manifestations and clinical prognosis of pediatric diffuse intrinsic pontine glioma (DIPG). Methods A total of 27 patients with complete clinical data of DIPG undergoing clinical treatment at Neurosurgery Department of Beijing Tiantan Hospital, Capital Medical University from November 2015 to November 2017 were retrospectively enrolled into this study. All patients were divided into 2 groups according to the presence of atypical manifestations: atypical clinical manifestation group (17 cases) and the control group (10 cases). Among the 27 cases, 16 patients underwent stereotactic biopsy or open cranial biopsy, and the other 11 patients underwent tumor excision through craniotomy. All the children were followed up clinically or by telephone after operation to study the clinical outcomes. Comparative analysis was conducted on those clinical data. Prognosis was compared between the 2 groups through Kaplan-Meier survival analysis. Results Among the 27 cases, 20 were pathologically identified as high grade gliomas (including 4 cases of diffuse midline glioma, 6 cases of glioblastoma, 6 cases of anaplastic oligoastrocytoma, 4 cases of anaplastic astrocytoma) and 7 as low grade glioma (including 4 cases of oligoastrocytoma and 3 cases of astrocytoma). One child suffered from pneumonia and finally recovered postoperatively. No statistically significant difference (all P>0.05) was identified between 2 groups in the age, gender, clinical manifestation (including cranial nerve palsy, long tract dysfunction and cerebellum signs), clinical imaging features (including lesion enhancement, supratentorial ventricle enlargement and brachium pontis involvement), clinical treatment or pathology. Kaplan-Meier survival analysis showed that patients with atypical clinical manifestation had significantly higher cumulative survival rate than those in the control group (P=0.045). Conclusion Atypical clinical manifestation could be identified in some pediatric DIPG patients, which might be predictive of a better prognosis. Key words: Brainstem tumor; Child; Atypical clinical manifestation

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华神经外科杂志 Medicine-Surgery

CiteScore

0.10

自引率

0.00%

发文量

10706

期刊介绍： Chinese Journal of Neurosurgery is one of the series of journals organized by the Chinese Medical Association under the supervision of the China Association for Science and Technology. The journal is aimed at neurosurgeons and related researchers, and reports on the leading scientific research results and clinical experience in the field of neurosurgery, as well as the basic theoretical research closely related to neurosurgery.Chinese Journal of Neurosurgery has been included in many famous domestic search organizations, such as China Knowledge Resources Database, China Biomedical Journal Citation Database, Chinese Biomedical Journal Literature Database, China Science Citation Database, China Biomedical Literature Database, China Science and Technology Paper Citation Statistical Analysis Database, and China Science and Technology Journal Full Text Database, Wanfang Data Database of Medical Journals, etc.