337. 不确定食管癌患者肺转移的预测

IF 2.3 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Maohui Chen, Zheng Bin, Hongjin Wang, Yizhou Huang, Shuliang Zhang, Zeng Taidui, Chen Chun
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引用次数: 0

摘要

不确定的肺结节(ipn)是食管癌术后常见的。食管癌术后ipn数据的缺乏导致了临床困境。本研究旨在探讨转移性食管癌根治性食管切除术后IPNs的特点及临床意义,确定肺转移的危险因素,构建风险评分模型,以规范患者随访或治疗的合适时间。2013年至2016年间连续接受根治性手术的食管鳞状细胞癌(ESCC)患者纳入本回顾性研究。进行单因素和多因素logistic回归分析,确定独立风险因素并建立风险评分模型。共有816名患者参加了这项研究。在中位随访45个月期间,221例(27.1%)患者检测到ipn,其中66例(29.9%)被诊断为肺转移。经多因素分析,病理N类型、IPNs数量、IPNs形状、IPNs检测时间、IPNs大小等5个变量对预后具有重要意义。肺转移预测模型(Pulmonary Metastasis Prediction Model, PMPM)评分范围为0 ~ 15分,得分越高的患者发生肺转移的可能性越大。经验证,PMPM量表鉴别效果良好,AUC为0.939。ESCC食管切除术患者ipn的PMPM量表可能对诊断和治疗决策有临床价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
337. PREDICTION OF PULMONARY METASTASIS IN ESOPHAGEAL CARCINOMA PATIENTS WITH INDETERMINATE
Indeterminate pulmonary nodules (IPNs) are common after surgery for esophageal cancer. The paucity of data on postoperative IPNs for esophageal cancer causes a clinical dilemma. The aim of this study was to identify the characteristics and clinical significance of IPNs after radical esophagectomy for metastatic esophageal cancer and determine the risk factors for pulmonary metastasis and construct a risk score model to standardize the appropriate time to either follow up or treat the patient. All consecutive patients with esophageal squamous cell carcinoma (ESCC) who underwent radical surgery between 2013 and 2016 were included in this retrospective study. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors and develop risk score models. A total of 816 patients were enrolled in the study. During a median follow-up period of 45 months, IPNs were detected in 221 (27.1%) patients, of whom 66 (29.9%) were diagnosed with pulmonary metastases. The following five variables maintained prognostic significance after multivariate analyses: the pathologic N category, number of IPNs, shape of IPNs, time of detection of IPNs, and size of IPNs. The Pulmonary Metastasis Prediction Model (PMPM) scale ranges from 0 to 15 points and patients with higher scores have a higher probability of pulmonary metastases. After validated, the PMPM scale showed good discrimination with an AUC of 0.939. A PMPM scale for IPNs in patients who underwent esophagectomy for ESCC may be clinically useful for diagnostic and therapeutic decision-making.
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来源期刊
Diseases of the Esophagus
Diseases of the Esophagus 医学-胃肠肝病学
CiteScore
5.30
自引率
7.70%
发文量
568
审稿时长
6 months
期刊介绍: Diseases of the Esophagus covers all aspects of the esophagus - etiology, investigation and diagnosis, and both medical and surgical treatment.
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