一种草药糖浆:配方和对雄性大鼠的抗抑郁作用

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
Sara Zakerin, H. Hajimehdipoor, S. Mortazavi, M. Sabetkasaei, R. Choopani, S. Fahimi
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引用次数: 0

摘要

草药在全球卫生保健系统中发挥着重要作用。在这项调查中,根据伊朗传统医学重新配制了一种多草药糖浆,并对其抗抑郁效果进行了评估。材料与方法:以薰衣草、金银花、紫堇、薏苡仁、甘草、红枣、小茴香、小茴香、小茴香、小茴香与甘油、山梨酸钾煎制糖浆。对糖浆的理化特性进行了研究。对糖浆进行了加速稳定性试验。此外,连续三周灌胃该药物(3.3 mL/kg/天),通过强迫游泳试验进行抗抑郁评估。测定大鼠血清5-羟色胺(5-HT)、去甲肾上腺素(NA)、脑源性神经营养因子(BDNF)水平。最后行肝、肾、脾组织病理检查。结果:所制得的草药糖浆呈褐色,具有独特的口感和风味。密度为1.085g/ml, pH值为5.56,粘度为5.35 cP,干残量为15.22%,总酚含量为194 mg/100 ml。在加速稳定性试验中,糖浆是稳定的,没有观察到明显的变化。在不影响BDNF水平的情况下,多药糖浆通过增加NA和5-HT水平来减少静止时间,显示出显著的抗抑郁作用。配方糖浆对肝、肾和脾也没有任何毒性作用。结论:经毒性试验和临床试验等补充试验,该糖浆可作为制药公司的合适候选产品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A herbal syrup: Formulation and antidepressant effect in male rat
Introduction: Herbal medicines play a significant role in global health-care systems. In this investigation, a polyherbal syrup has been reformulated pursuant to Iranian traditional medicine and its antidepressant effect has been evaluated. Materials and Methods: The syrup was prepared by decocting a mixture containing: Lavandula angustifolia, Melissa officinalis, Echium amoenum, Cordia myxa, Glycyrrhiza glabra, Ziziphus jujuba, Foeniculum vulgare, Fumaria parviflora, Adiantum capillus-veneris, and Alhagi spp. along with glycerin and potassium sorbate. Physicochemical characteristics of the syrup were examined. An accelerated stability test was carried out for syrup as well. Moreover, antidepressant evaluations were performed by the forced swimming test using the drug as gavage (3.3 mL/kg/day) for three consecutive weeks. The serum levels of serotonin (5-HT), noradrenaline (NA), and brain-derived neurotropic factor (BDNF) were determined in rats as well. Finally histopathological examinations were done on liver, kidney and spleen. Results: The herbal syrup was brown in color with a special taste and flavor. Density, pH, viscosity, dry residue, and total phenolics content were 1.085g/ml, 5.56, 5.35 cP, 15.22%, and 194 mg/100 mL, respectively. The syrup was stable during accelerated stability tests, and no significant changes were observed. The polyherbal syrup exhibited significant antidepressant effects by decreasing immobility time through increasing in NA and 5-HT levels without affecting BDNF levels. Formulated syrup also did not have any toxic effects on the liver, kidney, and spleen. Conclusion: The syrup could be an appropriate candidate for pharmaceutical companies after complementary tests such as toxicity and clinical trials.
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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