Role of oxidative stress in the efficacy and toxicity of herbal supplements

The importance of oxidative stress has been increasingly recognized in diabetes and related cardiovascular complications as well as in chemical-induced toxicity, which makes it a potential therapeutic target for tackling such health issues. On the other hand, numerous herbal supplements have been reported effective to prevent diabetes and chemical-induced organ injury. Recently, emerging studies indicate that antioxidation is a possible mechanism responsible for the therapeutic effect of herbal extracts. Hereby, we reviewed the most recent studies regarding the antioxidant effect of herbal supplements. Also, we summarized the herbal extracts causing hepatotoxicity and nephrotoxicity via oxidative stress. We aim to highlight the importance of oxidative stress in the therapeutic effectiveness of herbal supplements, as well as in mediating their adverse effects.