可生物降解磁性淀粉复合材料固定化铜纳米粒子对卵巢癌症细胞毒性和抗氧化作用的研究

IF 2.6 4区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of Experimental Nanoscience Pub Date : 2022-08-29 DOI:10.1080/17458080.2022.2110241

Ping Hou, Hongyi Kuang, Wei Deng, Yan Lei

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引用次数: 4

摘要

近年来，绿色合成的纳米磁性生物复合材料作为未来的催化剂具有巨大的发展潜力。这鼓励我们设计和合成一种新型的Cu NPs制备的马铃薯淀粉功能化磁性纳米材料(Fe3O4@starch/Cu纳米复合材料)。利用FT-IR、FESEM、TEM、EDX、元素图谱和ICP-OES等分析技术对所制备的纳米复合材料进行了表征。利用生物源性合成Fe3O4@starch/Cu纳米复合材料对卵巢癌细胞系(PA-1、Caov-3、SW 626和SK-OV-3)进行抗卵巢癌研究。该材料对卵巢癌细胞系具有明显的细胞毒性。然而，它对正常的HUVEC细胞系没有明显的活性。采用DPPH法研究了Fe3O4@starch/Cu纳米复合材料的抗氧化性能。根据IC50值，Fe3O4@starch/Cu纳米复合材料显示出显著的抗氧化潜力。

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Immobilized copper nanoparticles on biodegradable magnetic starch composite: investigation of its ovarian cancer, cytotoxicity, and antioxidant effects

Abstract In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Cu NPs fabricated potato starch functionalized magnetic nanomaterial (Fe3O4@starch/Cu nanocomposite). The prepared nanocomposite were characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, elemental mapping and ICP-OES. The biogenic synthesized Fe3O4@starch/Cu nanocomposite was explored in the anti-ovarian cancer investigations against ovarian cancer cell lines (PA-1, Caov-3, SW 626, and SK-OV-3). The material exhibited significant cytotoxicities against the ovarian cancer cell lines. However, it was considerably inactive against the normal HUVEC cell line. The antioxidant potential of Fe3O4@starch/Cu nanocomposite was also investigated by DPPH method. The Fe3O4@starch/Cu nanocomposite revealed the significant antioxidant potentials according to the IC50 value.

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来源期刊

Journal of Experimental Nanoscience 工程技术-材料科学：综合

CiteScore

4.10

自引率

25.00%

发文量

审稿时长

6.5 months

期刊介绍： Journal of Experimental Nanoscience, an international and multidisciplinary journal, provides a showcase for advances in the experimental sciences underlying nanotechnology and nanomaterials. The journal exists to bring together the most significant papers making original contributions to nanoscience in a range of fields including biology and biochemistry, physics, chemistry, chemical, electrical and mechanical engineering, materials, pharmaceuticals and medicine. The aim is to provide a forum in which cross fertilization between application areas, methodologies, disciplines, as well as academic and industrial researchers can take place and new developments can be encouraged.