镉盐对大鼠胚胎发生指标的毒性

IF 0.5 Q4 BIOLOGY
I. Kolosova, V. Shatorna
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引用次数: 0

摘要

镉是一种有毒重金属,被认为是一种危险的环境污染物,对生殖系统的器官、着床期和胚胎发育都有不利影响。本实验确定了镉盐(氯化物和柠檬酸盐)对胚胎发生一般过程的影响。为此,将60只大鼠随机分为三组:对照组、氯化镉暴露组和柠檬酸镉暴露组。在胚胎发生第1 ~ 13天(第一亚组)和胚胎发生第1 ~ 20天(第二亚组)分别注射剂量为1.0 mg/kg的氯化镉溶剂、柠檬酸镉溶剂和蒸馏水。在胚胎发生第13天和第20天,注射氯化镉组胚胎总数(分别是对照组的4.24倍和3.67倍)、着床前死亡率(分别是对照组的6.50倍和14.03倍)和着床后死亡率(分别是对照组的3.07倍和2.49倍)增加,存活胎数分别减少24.0%和25.9%。与此同时,与对照组相比,暴露于柠檬酸镉期间,胚胎总死亡率提高了4.02倍和3.52倍,着床前死亡率提高了6.04倍和13.03倍,着床后死亡率提高了3.09倍和2.26倍,活胎数指标降低了18.3%和22.2%。在测定妊娠第20天胚胎中镉的积累时,用电弧雾化原子发射法对生物材料进行了多元素分析,结果显示,与对照组相比,氯化镉增加了15.83倍,柠檬酸镉增加了9.00倍。两组动物的胚胎死亡率均升高,每只雌性活胎数下降,表明镉化合物具有明显的胚胎毒性作用。进行组织学研究将是有用的,这将有助于发现组织水平的变化,并可能解释胚胎死亡率的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicity of cadmium salts on indicators of embryogenesis of rats
Cadmium is a toxic heavy metal which is considered a dangerous environmental pollutant and has a detrimental effect on the organs of the reproductive system, the period of implantation and the development of embryos. The experiment presented in this article established the effect of cadmium salts (chloride and citrate) on the general progress of embryogenesis. For this purpose, 60 rats were randomly divided into three groups: control, experimental group with cadmium chloride exposure and experimental group with cadmium citrate exposure. Cadmium chloride solvent, cadmium citrate solvent at a dose of 1.0 mg/kg and distilled intragastric water were injected from the first to the thirteenth (first subgroup) and from the first to the twentieth days of embryogenesis (second subgroup). When cadmium chloride was injected, total embryonic (by 4.24 and 3.67 times), pre-implantation (by 6.50 and 14.03 times) and post-implantation mortality (by 3.07 and 2.49 times) increased with a reduction of the number of surviving fetuses by 24.0% and 25.9% compared with the control group on the 13th and 20th days of embryogenesis respectively. At the same time, during exposure to cadmium citrate, indicators of total embryonic mortality increased by 4.02 and 3.52 times, pre-implantation mortality by 6.04 and 13.03 times, and post-implantation mortality by 3.09 and 2.26 times, and indicators of the number of live fetuses decreased by 18.3% and 22.2% in relation to the control group. When determining the accumulation of cadmium in embryos on the 20th day of gestation, polyelement analysis of biological materials using the atomic emission method with electric arc atomization revealed a 15.83-fold increase in cadmium chloride and 9.00 times in cadmium citrate relative to the control group. Embryolethality rates increased in animals of both experimental groups while the number of live fetuses per female decreased, which indicated an obvious embryotoxic effect of cadmium compounds. It is would be useful to conduct histological studies, which will help detect changes at the tissue level and possibly explain the level of embryonic mortality.
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来源期刊
CiteScore
0.90
自引率
0.00%
发文量
25
审稿时长
10 weeks
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