巴西人多巴胺D2受体(DRD2)等位基因与快克/可卡因依赖性之间无相关性

Milena Binhame Albini Martini, I. Henn, I. T. Malacarne, C. M. Souza, P. Trevilatto, A. R. Vieira, L. Azevedo-Alanis
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引用次数: 0

摘要

引言:快克/可卡因使用背后的因果机制尚不清楚,但有人提出了遗传影响。目的:探讨多巴胺D2受体(DRD2)基因TaqI(rs1800497)多态性与可卡因依赖易感性的关系。方法:病例组(n=515)由依赖快克/可卡因的男性组成,对照组(n=106)由被认为不依赖快克或可卡因的男性构成。对口腔卫生习惯、龋齿、缺牙和补牙指数、牙龈指数和牙菌斑指数进行评估。利用实时聚合酶链反应技术对DRD2基因的参考单核苷酸多态性(rs1800497 C/T)进行基因分型。独立样本的Student t检验或非参数Mann-Whitney检验用于比较各组的定量变量。结果:病例组平均使用裂隙时间为9.91±7.03年,平均每周61.06±92.96结石。样本的社会人口特征是白人、单身男性、受过基础教育、蓝领工人、吸烟者和报告饮酒情况。牙龈炎症、牙菌斑积聚和龋齿的发生频率很高。在所有测试的遗传模型中,病例组和对照组之间DRD2基因rs1800497的基因型频率没有显著差异(p>0.05)。快克/可卡因依赖的复杂遗传性质和DRD2等位基因频率的巨大变化,取决于采样的人群,可能是没有关联的一种解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
No association between dopamine D2 receptor (DRD2) alleles and crack/cocaine dependence in Brazilians
Introduction: The causal mechanisms behind crack/cocaine use are still unknown, but genetic influences are suggested. Objective: To investigate the relationship between the genetic polymorphism TaqI (rs1800497) in the dopamine D2 receptor (DRD2) gene and susceptibility to crack/cocaine dependence in a group of addicts to crack/cocaine and a non-addicted group. Methods: The case group (n=515) was composed of crack/cocaine-dependent men and the control group (n=106) comprised men who were considered not dependent on crack/cocaine. The oral hygiene habits, decayed, missing, and filled teeth index, gingival index, and plaque index were evaluated. The reference single nucleotide polymorphism (rs1800497 C/T) of the DRD2 gene was genotyped by a real-time polymerase chain reaction technique. Student’s t-tests for independent samples or the non-parametric Mann-Whitney test were used to compare groups regarding quantitative variables. Results: The case group showed a mean time of 9.91±7.03 years of crack use, and 61.06±92.96 stones/week. The socio-demographic profile of the sample was White, single men, with basic education, blue-collar worker, smoker, and reporting alcohol use. There was a high frequency of gingival inflammation, plaque accumulation, and caries experience. For all genetic models tested, there was no significant difference in the genotypic frequency in rs1800497 of the DRD2 gene, between case and control groups (p>0.05). Conclusion: The genetic variant in the DRD2 did not increase the vulnerability to develop crack/cocaine dependence. The complex genetic nature of crack/cocaine dependence and a large variation of DRD2 allele frequencies, depending on the population group sampled, could be one explanation for the no association.
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