结核分枝杆菌介导泡沫巨噬细胞形成机制的研究进展

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2020-02-29 DOI:10.3760/CMA.J.CN112309-20190729-00233

Peng Wang, B. Yin, Yingjun Su

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引用次数: 0

摘要

泡沫巨噬细胞（FM），也称为泡沫样巨噬细胞，是指携带脂质的单核细胞或巨噬细胞。FM是一种在细胞质中富含脂滴的炎症细胞。在结核分枝杆菌（Mtb）引起的疾病中，如肉芽肿和结核性伤口，FM不仅会抑制免疫反应，还会影响预后和结果。Mtb感染引起的FM的形成机制具有一定的特异性，这可能是其在细胞中长期存活并影响疾病预后和结果的重要因素。因此，研究结核分枝杆菌介导的FM形成机制，有助于进一步揭示疾病的病理演变，为进一步精准治疗提供新思路。本文综述了近年来Mtb介导FM形成的机制。关键词：结核分枝杆菌；泡沫巨噬细胞；形成机制

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Research progress in the mechanisms of Mycobacterium tuberculosis-mediated formation of foamy macrophages

Foamy macrophages (FM), also known as foam-like macrophages, refer to lipid-laden monocytes or macrophages. FM are a kind of inflammatory cells that are rich in lipid droplets in cytoplasm. In the diseases caused by Mycobacterium tuberculosis (Mtb), such as granuloma and tuberculous wounds, FM can not only inhibit the immune response, but also affect the prognosis and outcomes. The formation mechanisms of FM caused by Mtb infection have some specificity, which may be an important factor for its long-term survival in cells and influences on disease prognosis and outcomes. Therefore, studying the mechanisms of Mtb-mediated formation of FM is conductive to further reveal the pathological evolution of diseases and provide new ideas for further precise treatment. This article reviewed the mechanisms of Mtb-mediated formation of FM in recent years. Key words: Mycobacterium tuberculosis; Foamy macrophages; Formation mechanism

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.