单阶段碎软骨修复

IF 0.4 4区 医学 Q4 SPORT SCIENCES
Bjørn B. Christensen , Martin Lind
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引用次数: 1

摘要

软骨损伤是出了名的难以治疗,而且不能自愈。现有的修复方法可能是昂贵的,往往提供不一致的临床和生物学结果。近年来,自体或异体颗粒软骨的应用已显示出良好的前景。软骨细胞可以从切碎的软骨中迁移,促进临床软骨的一步修复。文献中描述了四种不同的技术:“软骨自体移植植入系统”(CAIS)是将软骨活检组织切成1- 2mm的碎片,植入嵌入聚合物支架的软骨缺损中。“DeNovo NT天然组织移植物”是来自13岁以下供体的同种异体颗粒状幼年软骨。软骨被切成1mm3的小块,植入纤维蛋白胶包裹的软骨缺损中。“自体软骨碎”是将软骨活检切片切成0.25-0.5 mm3的薄片,包埋在纤维蛋白胶中,植入软骨或骨软骨缺损。该技术可配合或不配合植骨。在“增强自体碎软骨”技术中,添加了一种生物活性成分来增强修复过程。不同的碎软骨修复技术已显示出巨大的生物修复潜力,并提供临床效益。该技术易于应用,成本低,并且为外科医生提供了骨髓刺激和软骨细胞扩增和移植的替代方法。临床证据仍然有限,需要进一步的研究来确定碎软骨手术的临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Single Stage Minced Cartilage Repair

Cartilage injuries are notoriously difficult to treat and do not heal spontaneously. The available repair methods can be expensive and often provide an inconsistent clinical and biological outcome. The use of autologous or allogeneic particulated cartilage has shown promise in recent years. Chondrocytes can migrate from minced cartilage and facilitate clinical cartilage repair in one-step procedures. Four different techniques have been described in the literature: “The Cartilage Autograft Implantation System” (CAIS) is cartilage biopsies cut into 1- to 2-mm fragments and implanted in cartilage defects embedded in a polymer scaffold. “The DeNovo NT Natural tissue graft” is allogenic particulated juvenile cartilage from donors under the age of 13. The cartilage is cut into 1 mm3 dice and implanted in cartilage defects embedded in fibrin glue. “Autologous minced cartilage” is cartilage biopsies cut into 0.25-0.5 mm3 chips, embedded in fibrin glue and implanted in chondral or osteochondral defects. The technique can be used with or without concomitant bone grafting. In the “augmented autologous minced cartilage” technique, a bioactive component is added to augment the repair process. The different minced cartilage repair techniques have shown a great biological repair potential and provide clinical benefits. The techniques are easily applicable at a low cost, and they provide the surgeon with an alternative to marrow stimulation and chondrocyte expansion and transplantation. The clinical evidence is still limited, and further studies should be performed to establish the clinical efficacy of minced cartilage procedures.

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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
46
审稿时长
93 days
期刊介绍: Operative Techniques in Sports Medicine combines the authority of a textbook, the usefulness of a color atlas and the timeliness of a journal. Each issue focuses on a single clinical condition, offering several different management approaches. It''s the easiest way for practitioners to stay informed of the latest surgical advancements and developments.
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