波定对大鼠脊髓损伤后神经炎症的保护作用

IF 0.9 4区生物学 Q4 PLANT SCIENCES

Israel Journal of Plant Sciences Pub Date : 2021-08-27 DOI:10.1163/22238980-bja10041

Jigao Feng, Junchi Liu, Xu Liu, Zhaoyou Qiu, Caicai Zhang

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引用次数: 1

摘要

脊髓损伤（SCI）的成功临床治疗仍然是一个未满足的医疗需求。尽管新的治疗方法取得了进展，但SCI的多因素病因仍然对人类提出了重大挑战。因此，在本研究中，我们打算仔细研究Boldine（BOL）对实验性脊髓损伤的保护作用，Boldine是一种从boldo树中提取的生物碱。用氧化应激（MDA、SOD和GSH）、炎症（TNF-α、IL-1β和IL-6）和细胞凋亡等生物标志物研究了BOL对大鼠运动功能的影响。结果表明，BOL改善了大鼠的运动功能（在血脑屏障范围内），并减少了氧化应激和炎症。在流式细胞术实验中，它还能减少神经元凋亡。该研究成功地证明了BOL对抗SCI的可能临床效用。

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Protective effect of Boldine against neuroinflammation in spinal cord injury in rats

The successful clinical management of spinal cord injury (SCI) is still a unmet medical need. Despite advances in novel therapeutics, the multifactorial etiology of SCI still poses significant challenge to the mankind. Thus, in the present study, we intend to scrutinize the protective effect of Boldine (BOL), an alkaloid obtained from the boldo tree against experimental spinal cord injury. The effect of BOL was investigated on locomotor function of rats with various biomarkers of oxidative stress (MDA, SOD and GSH), inflammation (TNF-α, IL-1β and IL-6), and apoptosis. Results suggest that BOL showed improvement in locomotor function (on BBB scale) of rats with does-dependent reduction in oxidative stress and inflammation. It also reduces neuronal apoptosis in flow cytometry experiment. The study successfully demonstrated the possible clinical utility of BOL against SCI.

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来源期刊

Israel Journal of Plant Sciences 生物-植物科学

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Israel Journal of Plant Sciences is an international journal of extensive scope that publishes special issues dealing with all aspects of plant sciences, including but not limited to: physiology, cell biology, development, botany, genetic