人类与心血管疾病

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cor et vasa Pub Date : 2023-06-20 DOI:10.33678/cor.2022.057

Lutfu Askin, Okan Tanriverdi

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引用次数: 0

摘要

线粒体衍生肽（MDPs）由线粒体DNA编码。MDP包括人蛋白、c型核糖体核糖核酸（MOTS-c）和小的人蛋白样肽1-6（SHLP1-6）。在压力时期，它们支持线粒体活动和细胞存活。MDPs在体内外影响细胞存活、代谢、应激反应和炎症。最近的研究表明，MDPs在心血管疾病（CVD）的发展中发挥着重要作用。此外，可能的致病途径包括缺血、再灌注损伤、纤维化

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Humanin and Cardiovascular Diseases

Mitochondrial-derived peptides ( MDPs) are encoded by mitochondrial DNA. MDPs include humanin, ribosomal ribonucleic acid type c (MOTS-c), and small humanin-like peptides 1–6 (SHLP1–6). In times of stress, they support mitochondrial activity and cell survival. MDPs inﬂ uence cell survival, metabolism, stress response, and inﬂ ammation in vivo and in vitro . Recent research shows MDPs play a signiﬁ cant role in cardiovascular disease (CVD) development. In addition, possible pathogenic pathways include ischemia, reperfusion da- mage, ﬁ brosis

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来源期刊

Cor et vasa CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

0.50

自引率

50.00%

发文量